Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1465 - 1472 of 9359 hot products
| Catalog No. | Product Name |
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| BCC5863 | JMV 449 |
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Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.
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| BCC5864 | PL 017 |
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Selective <span class='symbol'>μ</span> opioid receptor agonist (IC<sub>50</sub> values are 5.5 and > 10000 nM for inhibition of <sup>125</sup>I-FK 33,824 and <sup>125</sup>I-DADLE binding to <span class='symbol'>μ</span> and <span class='symbol'>δ</span> sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administration in rats <em>in vivo</em>.
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| BCC5866 | 187-1, N-WASP inhibitor |
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Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>)-stimulated actin assembly (IC<sub>50</sub> ~ 2 <span class='symbol'>μ</span>M) but does not directly inhibit actin polymerization.
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| BCC5867 | K 41498 |
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Potent and highly selective CRF<sub>2</sub> receptor antagonist (K<sub>i</sub> values are 0.66, 0.62 and 425 nM for human CRF<sub>2<span class='symbol'>α</span></sub>, CRF<sub>2<span class='symbol'>β</span></sub> and CRF<sub>1</sub> receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF<sub>2<span class='symbol'>α</span></sub>- and hCRF<sub>2<span class='symbol'>β</span></sub>-expressing cells. In rats <em>in vivo</em>, blocks urocortin-induced hypotension following systemic administration.
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| BCC5868 | Antisauvagine-30 |
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Potent, selective and competitive corticotropin-releasing factor CRF<sub>2</sub> receptor antagonist (K<sub>d</sub> values are 1.4 and 153.6 nM for binding to mouse CRF<sub>2<span class='symbol'>β</span></sub> and rat CRF<sub>1</sub> receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF<sub>2<span class='symbol'>β</span></sub> cells (pA<sub>2</sub> = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice <em>in vivo</em>.
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| BCC5869 | PHM 27 (human) |
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Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC<sub>50</sub> = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic <span class='symbol'>β</span>-islets display enhanced glucose-induced insulin secretion.
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| BCC5870 | GIP (human) |
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Potent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Also affects lipid metabolism and displays mitogenic and antiapoptotic effects in pancreatic β-cells.
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| BCC5871 | Galnon |
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Novel non-peptide galanin GAL<sub>1</sub> and GAL<sub>2</sub> receptor agonist (K<sub>i</sub> values are 11.7 and 34.1 <span class='symbol'>μ</span>M respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active <em>in vivo</em>; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.
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