Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3125 | Tanshindiol C |
| 1. Tanshindiol C exhibits most powerful cytotoxic effects against tested tumor cells. 2. Tanshinones plays significant roles in the inhibition and induction of several CYP450 isozymes. | |
| BCN3127 | 6-Hydroxy-5,6-dehydrosugiol |
| 1. 6-Hydroxy-5,6-dehydrosugiol is a potent androgen receptor antagonist in prostate cancer cells, it has potential for use in chemoprevention and chemotherapy of prostate cancers. | |
| BCN3128 | Isochamaejasmine |
| Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. chamaejasme L. Isochamaejasmine shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 microM, but the selectivity was rather limited. | |
| BCN3129 | Neochamaejasmine A |
| Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately promoting the Fas-caspase 8-caspase 3 apoptotic machinery. | |
| BCN3130 | Neochamaejasmine B |
| Neochamaejasmine B displays nematicidal activity against both Bursaphelenchus xylophilus and Bursaphelenchus mucronatus. It can reduce seedling growth and disrupt root development, the IC50 value of 6.9 ug/mL . Neochamaejasmine B has antibacterial activity on Gram-positive bacterium and Gram-negative bacterium. | |
| BCN3131 | Isoneochamaejasmine A |
| 1. Isoneochamaejasmin A exhibits significantly nematicidal activities against both B. xylophilus and B. mucronatus. | |
| BCN3132 | Chamaejasmine |
| 1. Chamaejasmine inhibits Bcl-2 expression and induces Bax expression to desintegrate the outer mitochondrial membrane and causes cytochrome c release. 2. Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. | |
| BCN3133 | Sikokianin A |
| 1. Sikokianin A shows in vitro antiviral activity against HBsAg secretion. | |
