Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1409 - 1416 of 9359 hot products
| Catalog No. | Product Name |
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| BCC5807 | Hemopressin (rat) |
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Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. K<sub>i</sub> values are 27.76, 3.43 and 1.87 <span class='symbol'>μ</span>M respectively. Potent hypotensive <em>in vivo</em>. Also acts as a selective CB<sub>1</sub> receptor inverse agonist. Displays antinociceptive activity and induces hypophagia <em>in vivo</em>.
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| BCC5808 | Spantide I |
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Selective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo.
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| BCC5809 | GRP (porcine) |
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Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
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| BCC5810 | GRP (human) |
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Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
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| BCC5811 | PKC β pseudosubstrate |
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Selective cell-permeable peptide inhibitor of protein kinase C (IC<sub>50</sub> ~ 0.5 <span class='symbol'>μ</span>M). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.
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| BCC5812 | AF 12198 |
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Potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC<sub>50</sub> values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1<span class='symbol'>β</span> induction of IL-8 in human dermal fibroblasts. Reduces IL-1<span class='symbol'>β</span>-induced IL-6 production and exhibits anti-inflammatory activity <em>in vivo</em>.
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| BCC5813 | Ro 26-4550 trifluoroacetate |
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Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC<sub>50</sub> = 3 <span class='symbol'>μ</span>M for inhibition of IL-2 interaction with IL-2R <span class='symbol'>α</span>-subunit). Appears to compete with IL-2R<span class='symbol'>α</span> for its binding site on IL-2.
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| BCC5814 | OMDM-2 |
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Metabolically stable inhibitor of anandamide cellular uptake (K<sub>i</sub> = 3 <span class='symbol'>μ</span>M). Displays relatively low affinity for CB<sub>1</sub> and CB<sub>2</sub> receptors (K<sub>i</sub> values are 5.1 and > 10 <span class='symbol'>μ</span>M) and for vanilloid VR1 receptors (EC<sub>50</sub> = 10 <span class='symbol'>μ</span>M). Has minimal activity against FAAH (K<sub>i</sub> > 50 <span class='symbol'>μ</span>M). Active <em>in vivo</em>.
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