Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1417 - 1424 of 9359 hot products
| Catalog No. | Product Name |
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| BCC5815 | WKYMVM trifluoroacetate salt |
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Selective agonist for the formyl peptide receptors FPR2 and FPR3, expressed on immune cells. EC50 values for induction of calcium mobilization in FPR2-HL-60 cells and FPR3-HL-60 cells are 2 and 80 nM respectively.
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| BCC5816 | Trp-Lys-Tyr-Met-Val-Met |
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Selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.
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| BCC5817 | 2B-(SP) |
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Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3); derived from the phosphorylation site of the translation factor eIF2B.
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| BCC5818 | Threo-methylphenidate hydrochloride |
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Psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo.
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| BCC5819 | HS 014 |
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Potent and selective melanocortin MC<sub>4</sub> receptor antagonist (K<sub>i</sub> values are 3.16, 108, 54.4 and 694 nM for cloned human MC<sub>4</sub>, MC<sub>1</sub>, MC<sub>3</sub> and MC<sub>5</sub> receptors respectively). Increases food intake in rats and nociception in mice following central administration <em>in vivo</em>. Also inhibits IL-1<span class='symbol'>β</span>-induced Fos expression in the paraventricular hypothalamus.
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| BCC5820 | HS 024 |
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Highly potent melanocortin MC<sub>4</sub> receptor antagonist (K<sub>i</sub> values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC<sub>4</sub>, MC<sub>1</sub>, MC<sub>3</sub> and MC<sub>5</sub> receptors respectively). Increases food intake, and blocks <span class='symbol'>α</span>-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration <em>in vivo</em>.
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| BCC5821 | FRATide |
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Inhibitor of glycogen synthase kinase-3 (GSK-3); derived from FRAT1, the mammalian version of GSK-3-binding protein. Binds to GSK-3, inhibiting its interaction with axin, and also blocks GSK-3-catalyzed phosphorylation of axin and β-catenin. Does not affect GSK-3-mediated phosphorylation of glycogen synthase or eIF2B.
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| BCC5822 | BIM 23127 |
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Neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 20.9 and > 10000 nM for NMB and gastrin-releasing peptide receptors respectively). Selectively blocks NMB-suppressed glucose intake in vivo. Also a potent urotensin-II receptor antagonist (pA2 = 7.5 - 7.7) and displays affinity for somatostatin and μ-opioid receptors.
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