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Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN6120	Bulleyanin
1. Bulleyanin shows strong inhibition of mouse ehrlich ascites carcinoma (ECA), mouse sarcoma S-180, and mouse liver ascites.
BCN6125	6-O-Vanilloylajugol
1. 6-O-Vanilloylajugol demonstrates scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.
BCN6127	Cannabidiolic acid
1. Cannabidiolic acid (CBDA) inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA; it offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers. 2. Cannabidiolic acid displays significantly greater potency at inhibiting vomiting in shrews and nausea in rats, and at enhancing 5-HT(1A) receptor activation, an action that accounts for its ability to attenuate conditioned gaping in rats. 3. Cannabidiolic acid selectively inhibits cyclooxygenase (COX)-2 activity with an IC(50) value around 2 microM, has 9-fold higher selectivity than COX-1 inhibition. 4. Cannabidiolic acid and cannabidiol have inhibitory actions on the intestines of S. murinus that are not neuronallymediated or mediated via CB1 or CB2 receptors.
BCN6131	26-Nor-8-oxo-alpha-onocerin
1. 26-Nor-8-oxo-alpha-onocerin can promote the osteoblast proliferation rate, the effect is time-dependent,concentration-dependent and differentiation state-dependent.
BCN6134	6-Acetonyl-N-methyl-dihydrodecarine
1. 6-Acetonyl- N -methyl-dihydrodecarine has mosquito larvicidal activity against the malaria vector Anopheles gambiae.
BCN6135	Cedrelone
1. Cedrelone exhibits antifeedant activity. 2. Cedrelone and its derivatives exert antimicrobial activities, bromohydroxy cedrelone and Michael adduct show good antifungal activity. 3. Cedrelone and dysobinin show significant cytotoxicity against cancer cell lines, such as -60, SMMC-7721, A-549, MCF-7 and SW480. 4. Cedrelone is a very potent inducers of apoptosis, it can cause cell cycle arrest. 5. Cedrelone has insecticidal activity, it inhibits arval growth of P. saucia, and the molting of the milkweed bug, Oncopeltus fasciatus.
BCN6136	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
1. 5,7,3',5'-Tetrahydroxy-6,4'-dimethoxyflavone exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity. 2. 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase.
BCN6137	24-Methylenecycloartanol acetate
1. 24-Methylenecycloartanol acetate has antiviral and antimicrobial activities.