Hot Natural Products & Bioactive Compounds

Engeletin, a bioactive flavonoid, has multiple biological activities such as anti-diabetic and anti-inflammatory effects. Engeletin possesses potent inhibition of PGE2 release with IC50 values of 19.6 μg/ml; it inhibits a recombinant human aldose reductase (IC50 value=1.16 microM).

1. Boehmenan exhibits cytotoxicity against both Wnt-dependent (HCT116) and Wnt-independent (RKO) cells, it decreases the expression of full, cytosolic and nuclear β-catenin along with c-myc in STF/293 cells, suggestes that boehmenan may have inhibited the Wnt signal by decreasing β-catenin levels.
2. (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 um, it inhibits PTP1B activity in a competitive manner.
3. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells.

1. Liriodendrin has anti-inflammatory and antinociceptive activities.
2. Liriodendrin shows an excellent hypoglycemic activity.
3. Liriodendrin has protective effects on dopamine-induced cytotoxicity via its anti-oxidative properties by reducing ROS level and anti-apoptotic effect via protection of mitochondrion membrane potential (ΔΨm).
4. Liriodendrin may be a potent suppressor of CaCl(2)-induced arrhythmias, the prophylactic administration of liriodendrin is effective in prolonging latency of arrhythmia and reducing the occurrence of ventricular fibrillation from 75% to 25%.
5. Liriodendrin has inhibitory activities on gastritis and gastric ulcer, it can inhibit colonization of Helicobacter pylori effectively, it could be utilized for the treatment and/or protection of gastritis and gastric ulcer.
6. Liriodendrin plays protective role in sepsis-induced acute lung injury, it regulates lung inflammation, the phosphorylation of the NF-kB (p65) and expression of vascular endothelial growth factor (VEGF).

8-O-Acetylshanzhiside methyl ester(ND01) has potential against cerebral ischemic injury and experimental myocardial ischemia injury, it can increase angiogenesis and improve functional recovery after stroke. ND01 protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.

1. Stigmast-4-ene-3,6-dione has anti-inflammatory and anti-allergic properties.

1. Carpachromene blocks protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated macrophages, it could be a potential anti-inflammatory agent.
2. Carpachromene exhibits significant cytotoxicity against HepG2, PLC/PRF/5 and Raji cancer cell lines in vitro.
3. Carpachromene shows significant α-glucosidase inhibitory activity.

Sucrose is used extensively as a food and a sweetener, it is the most efficient large-scale crop capable of supplying sufficient carbon substrate, in the form of Sucrose, needed during fermentative feedstock production.

1. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apoptosis in cancer cells.
2. Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases.
3. Isofuranodiene can induce apoptosis in colon cancer cells in a time and concentration-dependent manner suggesting a potential role as models for the development of chemopreventive agents.
4. Isofuranodiene at concentrations of 25 and 12.5 lM alone, or in combination with 50 nM nerve growth factor (NGF) , shows a marked stimulation of neuritogenesis,which appears to be a promising neurotrophic and neuroprotective agent.