Hot Natural Products & Bioactive Compounds

1. Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug.
2. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 value of 6.8 uM, it also exhibits cytotoxic activity towards the MOLT-3 cell line with IC50 values of 3.9 uM.

1. Stigmasta-4,22-dien-3-one has antioxidant activity.

1. alpha- and beta-Amyrin have hepatoprotective potential against toxic liver injury, the diminution in oxidative stress and toxic metabolite formation as likely mechanisms involved in its hepatoprotection.
2. alpha- and beta-Amyrin have antinociceptive properties in inflammatory models of pain, the mechanisms involved in their action are not completely understood but seem to involve the inhibition of protein kinase A- and protein kinase C-sensitive pathways.
3. alpha- and beta-Amyrin have anti-inflammatory potential, they retard acute inflammation in rat model of periodontitis and warrant further study on its efficacy to prevent chronic periodontitis-associated bone loss.
4. alpha- and beta-Amyrin mixture has gastro-protective activity, the mechanism involves at least in part the activation of capsaicin-sensitive primary afferent neurons.
5. alpha- and beta-Amyrin mixture has sedative and anxiolytic effects, the mechanism may involve an action on benzodiazepine-type receptors, and also an antidepressant effect where noradrenergic mechanisms will probably play a role.
6. Beta-Amyrin can enhance the total sleeping behavior in pentobarbital-induced sleeping model via the activation of GABAergic neurotransmitter system through GABA content in the brain.
7. beta-Amyrin has antiviral activity.

Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.Friedelin rich fraction (IND-HE) shows estrogenic activity as indicated by vaginal cornification, increase in uterine weight and rise in serum estrogen. Friedelin may be beneficial to mimic insulin action that would be useful in the treatment of diabetes type 2 patients.

1.Asperglaucide shows some nematocidal property against M. incognita .

Porson exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 40.0 μg/mL.

3-(2,4-Dihydroxyphenyl)propionic acid and l-ascorbic acid show tyrosinase inhibition activity, a synergistic effect on tyrosinase inhibition was observed when the two compounds were mixed.

Standard reference