Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC6752 | 3'-Fluorobenzylspiperone maleate |
| A very potent and selective ligand for the D2 receptor (Ki = 0.023 nM). Compared with spiperone, displays a 2.5-fold greater affinity at D2 and a 12-fold lower affinity at 5-HT2 receptors. | |
| BCC6753 | BTCP maleate |
| A potent dopamine re-uptake inhibitor with a behavioral profile different from that of PCP and similar to that of cocaine. | |
| BCC6754 | Anpirtoline hydrochloride |
| Highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively). Decreases central serotonin synthesis and attenuates aggressive behavior in vivo. Also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant. | |
| BCC6755 | L-701,252 |
| An antagonist at the glycine-NMDA site (IC50 = 420 nM). Also a potent systemic anticonvulsant. | |
| BCC6756 | 7-Hydroxy-DPAT hydrobromide |
| D3 dopamine receptor agonist (Ki values are ~ 1, 10, 650 and ~ 5000 nM for D3, D2, D4 and D1 receptors respectively). (R)-(+)-8-Hydroxy-DPAT hydrobromide and 8-Hydroxy-DPAT hydrobromide also available. | |
| BCC6757 | 2-Hydroxypropyl-β-cyclodextrin |
| The most widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with HBC. | |
| BCC6758 | MAP4 |
| Group II metabotropic glutamate receptor antagonist in electrophysiological studies and at cloned receptors. Group II mGlu agonist in adult rat cerebrocortical slices. | |
| BCC6759 | Cyclothiazide |
| Positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits. Also available as part of the AMPA Receptor. | |
