Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC6887 | N-Desmethylclozapine |
| A major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist. | |
| BCC6888 | E4CPG |
| Novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG. | |
| BCC6889 | QX 314 bromide |
| Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons. | |
| BCC6890 | RS 16566 dihydrochloride |
| High affinity ligand for the (R)-zacopride binding site (pKi 9.84 ). | |
| BCC6891 | LY 225910 |
| Potent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes). | |
| BCC6892 | LY 235959 |
| Competitive NMDA receptor antagonist. | |
| BCC6894 | Nisoxetine hydrochloride |
| A potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors. | |
| BCC6898 | Piribedil dihydrochloride |
| A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors. | |
