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12-Hydroxymyricanone

CAS# 191999-68-5

12-Hydroxymyricanone

Catalog No. BCN8046----Order now to get a substantial discount!

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Quality Control of 12-Hydroxymyricanone

Number of papers citing our products

Chemical structure

12-Hydroxymyricanone

3D structure

Chemical Properties of 12-Hydroxymyricanone

Cas No. 191999-68-5 SDF Download SDF
PubChem ID 10714326 Appearance Powder
Formula C21H24O6 M.Wt 372.41
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES COC1=C(C(=C2CCCCC(=O)C(CC3=CC(=C(C=C3)O)C1=C2)O)O)OC
Standard InChIKey MZTZAESUYFUQBV-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H24O6/c1-26-20-15-11-13(19(25)21(20)27-2)5-3-4-6-17(23)18(24)10-12-7-8-16(22)14(15)9-12/h7-9,11,18,22,24-25H,3-6,10H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 12-Hydroxymyricanone

The root bark of Myrica cerifera L.

Biological Activity of 12-Hydroxymyricanone

Description1. 12-Hydroxymyricanone exhibits anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and the MIC value of 35.8 ug/mL. 2. 12-Hydroxymyricanone inhibits the release of nitric oxide with the IC(50) value of 30.19 muM.
TargetsAntifection | NO | NOS

12-Hydroxymyricanone Dilution Calculator

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12-Hydroxymyricanone Molarity Calculator

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Preparing Stock Solutions of 12-Hydroxymyricanone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6852 mL 13.4261 mL 26.8521 mL 53.7043 mL 67.1303 mL
5 mM 0.537 mL 2.6852 mL 5.3704 mL 10.7409 mL 13.4261 mL
10 mM 0.2685 mL 1.3426 mL 2.6852 mL 5.3704 mL 6.713 mL
50 mM 0.0537 mL 0.2685 mL 0.537 mL 1.0741 mL 1.3426 mL
100 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.537 mL 0.6713 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 12-Hydroxymyricanone

Biological evaluation of secondary metabolites from the roots of Myrica adenophora.[Pubmed:24810013]

Phytochemistry. 2014 Jul;103:89-98.

Bioassay-guided fractionation of the roots of Myrica adenophora led to isolation of 24 known compounds and hitherto unknown compounds, including three A-type proanthocyanidins [adenodimerins A-C], two esters of sucrose [myricadenins A and B ], and the phenolic glycoside 6'-O-galloyl orbicularin. Spectroscopic analyses were used to determine their structures. Adenodimerin A, myricananin C, and myricetin showed strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities, with SC50 values of 7.9, 16.3, and 15.9 muM, respectively. Adenodimerin A, myricanone, myricananin C, (-)-myricanol, myricanol 11-O-beta-D-glucopyranoside, and myricetin showed stronger 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical scavenging activities than the positive control, with SC50 values of 7.5, 19.6, 12.0, 22.3, 19.6, and 15.6 muM, respectively. 5-Deoxymyricanone, porson, 12-Hydroxymyricanone (-)-myricanol, and (+)-galeon exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 25.8, 40.0, 35.8, 30.0, and 15.0 mug/mL, respectively. Myricadenin A, myricanone, myricananin C, and (-)-myricanol exhibited anti-inflammatory activities in the iNOS assay with EC50 values of 18.1, 1.00, 13.0, and 7.5 muM, respectively.

Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release.[Pubmed:18723353]

Bioorg Med Chem. 2008 Sep 15;16(18):8510-5.

Investigation of the roots of Myrica nana afforded five new cyclic diarylheptanoids, myricananins A-E (1-5), two new artifacts of myricananins A and B (6-7), and four known compounds, 12-Hydroxymyricanone (8), alnusonol (9), myricatomentogenin (10), and actinidione (11). The structures of these new compounds were established by detailed spectroscopic methods. The stereochemistry of compounds 1 and 2 were determined by single-crystal X-ray diffraction. In exception of compounds 2, 6 and 10, all the other compounds were examined for their inhibitory effects on nitric oxide production in lipopolysaccharides-activated macrophages. Compounds 1, 3, 7, 8 and 9 inhibited the release of nitric oxide with IC(50) values of 45.32, 63.51, 52.81, 30.19 and 46.18muM, respectively. Furthermore, compound 1 was found to inhibit the expression of inducible nitric oxide synthase.

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