12-HydroxymyricanoneCAS# 191999-68-5 |
Quality Control & MSDS
3D structure
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| Cas No. | 191999-68-5 | SDF | Download SDF |
| PubChem ID | 10714326 | Appearance | Powder |
| Formula | C21H24O6 | M.Wt | 372.41 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | COC1=C(C(=C2CCCCC(=O)C(CC3=CC(=C(C=C3)O)C1=C2)O)O)OC | ||
| Standard InChIKey | MZTZAESUYFUQBV-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C21H24O6/c1-26-20-15-11-13(19(25)21(20)27-2)5-3-4-6-17(23)18(24)10-12-7-8-16(22)14(15)9-12/h7-9,11,18,22,24-25H,3-6,10H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 12-Hydroxymyricanone exhibits anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and the MIC value of 35.8 ug/mL. 2. 12-Hydroxymyricanone inhibits the release of nitric oxide with the IC(50) value of 30.19 muM. |
| Targets | Antifection | NO | NOS |
12-Hydroxymyricanone Dilution Calculator
12-Hydroxymyricanone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6852 mL | 13.4261 mL | 26.8521 mL | 53.7043 mL | 67.1303 mL |
| 5 mM | 0.537 mL | 2.6852 mL | 5.3704 mL | 10.7409 mL | 13.4261 mL |
| 10 mM | 0.2685 mL | 1.3426 mL | 2.6852 mL | 5.3704 mL | 6.713 mL |
| 50 mM | 0.0537 mL | 0.2685 mL | 0.537 mL | 1.0741 mL | 1.3426 mL |
| 100 mM | 0.0269 mL | 0.1343 mL | 0.2685 mL | 0.537 mL | 0.6713 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Biological evaluation of secondary metabolites from the roots of Myrica adenophora.[Pubmed:24810013]
Phytochemistry. 2014 Jul;103:89-98.
Bioassay-guided fractionation of the roots of Myrica adenophora led to isolation of 24 known compounds and hitherto unknown compounds, including three A-type proanthocyanidins [adenodimerins A-C], two esters of sucrose [myricadenins A and B ], and the phenolic glycoside 6'-O-galloyl orbicularin. Spectroscopic analyses were used to determine their structures. Adenodimerin A, myricananin C, and myricetin showed strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities, with SC50 values of 7.9, 16.3, and 15.9 muM, respectively. Adenodimerin A, myricanone, myricananin C, (-)-myricanol, myricanol 11-O-beta-D-glucopyranoside, and myricetin showed stronger 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical scavenging activities than the positive control, with SC50 values of 7.5, 19.6, 12.0, 22.3, 19.6, and 15.6 muM, respectively. 5-Deoxymyricanone, porson, 12-Hydroxymyricanone (-)-myricanol, and (+)-galeon exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 25.8, 40.0, 35.8, 30.0, and 15.0 mug/mL, respectively. Myricadenin A, myricanone, myricananin C, and (-)-myricanol exhibited anti-inflammatory activities in the iNOS assay with EC50 values of 18.1, 1.00, 13.0, and 7.5 muM, respectively.
Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release.[Pubmed:18723353]
Bioorg Med Chem. 2008 Sep 15;16(18):8510-5.
Investigation of the roots of Myrica nana afforded five new cyclic diarylheptanoids, myricananins A-E (1-5), two new artifacts of myricananins A and B (6-7), and four known compounds, 12-Hydroxymyricanone (8), alnusonol (9), myricatomentogenin (10), and actinidione (11). The structures of these new compounds were established by detailed spectroscopic methods. The stereochemistry of compounds 1 and 2 were determined by single-crystal X-ray diffraction. In exception of compounds 2, 6 and 10, all the other compounds were examined for their inhibitory effects on nitric oxide production in lipopolysaccharides-activated macrophages. Compounds 1, 3, 7, 8 and 9 inhibited the release of nitric oxide with IC(50) values of 45.32, 63.51, 52.81, 30.19 and 46.18muM, respectively. Furthermore, compound 1 was found to inhibit the expression of inducible nitric oxide synthase.
