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2',5,7-Trihydroxy-8-methoxyflavanone

CAS# 112408-71-6

2',5,7-Trihydroxy-8-methoxyflavanone

Catalog No. BCN6004----Order now to get a substantial discount!

Product Name & Size Price Stock
2',5,7-Trihydroxy-8-methoxyflavanone: 5mg Please Inquire In Stock
2',5,7-Trihydroxy-8-methoxyflavanone: 10mg Please Inquire In Stock
2',5,7-Trihydroxy-8-methoxyflavanone: 20mg Please Inquire Please Inquire
2',5,7-Trihydroxy-8-methoxyflavanone: 50mg Please Inquire Please Inquire
2',5,7-Trihydroxy-8-methoxyflavanone: 100mg Please Inquire Please Inquire
2',5,7-Trihydroxy-8-methoxyflavanone: 200mg Please Inquire Please Inquire
2',5,7-Trihydroxy-8-methoxyflavanone: 500mg Please Inquire Please Inquire
2',5,7-Trihydroxy-8-methoxyflavanone: 1000mg Please Inquire Please Inquire

Quality Control of 2',5,7-Trihydroxy-8-methoxyflavanone

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Chemical structure

2',5,7-Trihydroxy-8-methoxyflavanone

3D structure

Chemical Properties of 2',5,7-Trihydroxy-8-methoxyflavanone

Cas No. 112408-71-6 SDF Download SDF
PubChem ID 13889012 Appearance Powder
Formula C16H14O6 M.Wt 302.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S)-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-methoxy-2,3-dihydrochromen-4-one
SMILES COC1=C(C=C(C2=C1OC(CC2=O)C3=CC=CC=C3O)O)O
Standard InChIKey URBNKMKLIWQQRO-ZDUSSCGKSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2',5,7-Trihydroxy-8-methoxyflavanone

The roots of Scutellaria baicalensis Georgi

Biological Activity of 2',5,7-Trihydroxy-8-methoxyflavanone

Description1. 2',5,7-Trihydroxy-8-methoxyflavanone has cytotoxic activity.

2',5,7-Trihydroxy-8-methoxyflavanone Dilution Calculator

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2',5,7-Trihydroxy-8-methoxyflavanone Molarity Calculator

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Preparing Stock Solutions of 2',5,7-Trihydroxy-8-methoxyflavanone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.308 mL 16.5399 mL 33.0797 mL 66.1594 mL 82.6993 mL
5 mM 0.6616 mL 3.308 mL 6.6159 mL 13.2319 mL 16.5399 mL
10 mM 0.3308 mL 1.654 mL 3.308 mL 6.6159 mL 8.2699 mL
50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.3232 mL 1.654 mL
100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.6616 mL 0.827 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2',5,7-Trihydroxy-8-methoxyflavanone

Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes.[Pubmed:28987606]

Eur J Med Chem. 2017 Nov 10;140:448-464.

A series of novel berberine derivatives, 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines was designed, synthesized, and biologically evaluated for their anti-diabetic activity. Following the evaluation in two types of cells, compounds 4aa, 4bq, and 4bv stimulated glucose consumption (1.8- to 2.3-fold), reduced gluconeogenesis (60-85%), inhibited mitochondria respiratory chain complex I and activated AMPK indirectly. In a db/db mice model, compounds 4bq and 4bv lowered fasting blood glucose at a dose of 120 mg/kg/day. In addition, compounds 4bq and 4bv were found to possess improved pharmacokinetic profiles (bioavailability 45 and 106%, respectively) compared to berberine. Compounds 4bq and 4bv exhibited no obvious hERG inhibition (IC50 > 10 muM).

Control of alpha/beta Anomer Formation by a 2',5' Bridge: Toward Nucleoside Derivatives Locked in the South Conformation.[Pubmed:28972760]

J Org Chem. 2017 Nov 3;82(21):11337-11347.

We describe a novel stereoselective synthesis of nucleoside derivatives with the ribose ring locked in the South conformation by a bridge between C2' and C5'. Despite the intrinsic constraints of the bicyclic structure, we demonstrate that their synthesis can be achieved by ring closing metathesis of readily accessible precursors. The obtained ribose derivatives are, however, very poor substrates for further installation of the nucleobases, and even simple nucleophiles, such as azido or cyano anions, react with unexpected stereo- or regioselectivity under standard glycosylation conditions. Here we explain this behavior by employing density functional theory (DFT) computations and devise an alternative approach resulting in isomers with the desired orientation of the nucleobase.

Carborane-linked 2'-deoxyuridine 5'-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA.[Pubmed:29017785]

Bioorg Med Chem Lett. 2017 Nov 1;27(21):4786-4788.

5-[(p-Carborane-2-yl)ethynyl]-2'-deoxyuridine 5'-O-triphosphate was synthesized and used as a good substrate in enzymatic construction of carborane-modified DNA or oligonucleotides containing up to 21 carborane moieties in primer extension reactions by DNA polymerases.

Triplex- and Duplex-Forming Abilities of Oligonucleotides Containing 2'-Deoxy-5-trifluoromethyluridine and 2'-Deoxy-5-trifluoromethylcytidine.[Pubmed:28966282]

Chem Pharm Bull (Tokyo). 2017;65(10):982-988.

A facile synthesis of 2'-deoxy-5-trifluoromethyluridine and 2'-deoxy-5-trifluoromethylcytidine phosphoramidites from commercially available 2'-deoxyuridine and 2'-deoxycytidine was achieved, respectively. The obtained phosphoramidites were incorporated into oligonucleotides, and their binding affinity to double-stranded DNA (dsDNA) and single-stranded RNA (ssRNA) was evaluated by UV-melting experiments. The triplex-forming abilities of oligonucleotides including 5-trifluoromethylpyrimidine nucleobases with dsDNA were decreased. Especially, the stability of the triplex containing a trifluoromethylcytosine ((CF3)C)-GC base triplet was low, likely due to the low pKa of protonated (CF3)C by the electron-withdrawing trifluoromethyl group. A slight decrease in stability of the duplex formed with ssRNA by oligonucleotides including 5-trifluoromethylpyrimidine nucleobases was only observed, suggesting that they might be applicable to various ssRNA-targeted technologies using features of fluorine atoms.

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