6-Aminonicotinic acidCAS# 3167-49-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 3167-49-5 | SDF | Download SDF |
PubChem ID | 18496 | Appearance | Powder |
Formula | C6H6N2O2 | M.Wt | 138 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 6-aminopyridine-3-carboxylic acid | ||
SMILES | C1=CC(=NC=C1C(=O)O)N | ||
Standard InChIKey | ZCIFWRHIEBXBOY-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C6H6N2O2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H2,7,8)(H,9,10) | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
6-Aminonicotinic acid Dilution Calculator
6-Aminonicotinic acid Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 7.2464 mL | 36.2319 mL | 72.4638 mL | 144.9275 mL | 181.1594 mL |
5 mM | 1.4493 mL | 7.2464 mL | 14.4928 mL | 28.9855 mL | 36.2319 mL |
10 mM | 0.7246 mL | 3.6232 mL | 7.2464 mL | 14.4928 mL | 18.1159 mL |
50 mM | 0.1449 mL | 0.7246 mL | 1.4493 mL | 2.8986 mL | 3.6232 mL |
100 mM | 0.0725 mL | 0.3623 mL | 0.7246 mL | 1.4493 mL | 1.8116 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Palifosfamide
Catalog No.:BCC1833
CAS No.:31645-39-3
- 9-Anthracenylmethyl acrylate
Catalog No.:BCC8798
CAS No.:31645-34-8
- 5,7-Dihydroxy-6,8-dimethoxyflavone
Catalog No.:BCN5235
CAS No.:3162-45-6
- Artocarpesin
Catalog No.:BCN8071
CAS No.:3162-09-2
- SCH 442416
Catalog No.:BCC7372
CAS No.:316173-57-6
- Moroxydine HCl
Catalog No.:BCC4802
CAS No.:3160-91-6
- Z-Ile-OH
Catalog No.:BCC2593
CAS No.:3160-59-6
- Z-Asp(OMe)-OH
Catalog No.:BCC2790
CAS No.:3160-47-2
- Emetine dihydrochloride
Catalog No.:BCN8307
CAS No.:316-42-7
- Berberine Sulphate
Catalog No.:BCC8131
CAS No.:316-41-6
- Heraclenol
Catalog No.:BCN5234
CAS No.:31575-93-6
- 4EGI-1
Catalog No.:BCC5337
CAS No.:315706-13-9
- Gatifloxacin mesylate
Catalog No.:BCC4225
CAS No.:316819-28-0
- Pinusolide
Catalog No.:BCN5236
CAS No.:31685-80-0
- Levomefolic acid
Catalog No.:BCC1703
CAS No.:31690-09-2
- Aminophylline
Catalog No.:BCC2300
CAS No.:317-34-0
- Hesperetin 7-O-glucoside
Catalog No.:BCN5237
CAS No.:31712-49-9
- 5,7-Dihydroxychromone
Catalog No.:BCN4652
CAS No.:31721-94-5
- 3,5,7-Trihydroxychromone
Catalog No.:BCN7479
CAS No.:31721-95-6
- GW501516
Catalog No.:BCC2268
CAS No.:317318-70-0
- GW0742
Catalog No.:BCC2267
CAS No.:317318-84-6
- O-1602
Catalog No.:BCC7487
CAS No.:317321-41-8
- TCS 2314
Catalog No.:BCC6080
CAS No.:317353-73-4
- 2-Methyl-4-(2-methylbenzoylamino)benzoic acid
Catalog No.:BCC8579
CAS No.:317374-08-6
Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists.[Pubmed:25038482]
Eur J Med Chem. 2014 Sep 12;84:404-16.
A series of 6-Aminonicotinic acid analogues have been synthesized and pharmacologically characterized at native and selected recombinant GABA(A) receptors. 6-Aminonicotinic acid (3) as well as 2- and 4-alkylated analogues (9-11, 14-16) display low to mid-micromolar GABA(A)R binding affinities to native GABA(A) receptors (K(i) 1.1-24 muM). The tetrahydropyridine analogue of 3 (22) shows low-nanomolar affinity (K(i) 0.044 muM) and equipotency as an agonist to GABA itself as well as the standard GABA(A) agonist isoguvacine. Cavities surrounding the core of the GABA binding pocket were predicted by molecular interaction field calculations and docking studies in a alpha1beta2gamma2 GABA(A) receptor homology model, and were confirmed by affinities of substituted analogues of 3. The tight steric requirements observed for the remarkably few GABA(A)R agonists reported to date is challenged by our findings. New openings for agonist design are proposed which potentially could facilitate the exploration of different pharmacological profiles within the GABA(A)R area.