6-Aminonicotinic acidCAS# 3167-49-5 |
Quality Control & MSDS
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| Cas No. | 3167-49-5 | SDF | Download SDF |
| PubChem ID | 18496 | Appearance | Powder |
| Formula | C6H6N2O2 | M.Wt | 138 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 6-aminopyridine-3-carboxylic acid | ||
| SMILES | C1=CC(=NC=C1C(=O)O)N | ||
| Standard InChIKey | ZCIFWRHIEBXBOY-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C6H6N2O2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H2,7,8)(H,9,10) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
6-Aminonicotinic acid Dilution Calculator
6-Aminonicotinic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 7.2464 mL | 36.2319 mL | 72.4638 mL | 144.9275 mL | 181.1594 mL |
| 5 mM | 1.4493 mL | 7.2464 mL | 14.4928 mL | 28.9855 mL | 36.2319 mL |
| 10 mM | 0.7246 mL | 3.6232 mL | 7.2464 mL | 14.4928 mL | 18.1159 mL |
| 50 mM | 0.1449 mL | 0.7246 mL | 1.4493 mL | 2.8986 mL | 3.6232 mL |
| 100 mM | 0.0725 mL | 0.3623 mL | 0.7246 mL | 1.4493 mL | 1.8116 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists.[Pubmed:25038482]
Eur J Med Chem. 2014 Sep 12;84:404-16.
A series of 6-Aminonicotinic acid analogues have been synthesized and pharmacologically characterized at native and selected recombinant GABA(A) receptors. 6-Aminonicotinic acid (3) as well as 2- and 4-alkylated analogues (9-11, 14-16) display low to mid-micromolar GABA(A)R binding affinities to native GABA(A) receptors (K(i) 1.1-24 muM). The tetrahydropyridine analogue of 3 (22) shows low-nanomolar affinity (K(i) 0.044 muM) and equipotency as an agonist to GABA itself as well as the standard GABA(A) agonist isoguvacine. Cavities surrounding the core of the GABA binding pocket were predicted by molecular interaction field calculations and docking studies in a alpha1beta2gamma2 GABA(A) receptor homology model, and were confirmed by affinities of substituted analogues of 3. The tight steric requirements observed for the remarkably few GABA(A)R agonists reported to date is challenged by our findings. New openings for agonist design are proposed which potentially could facilitate the exploration of different pharmacological profiles within the GABA(A)R area.
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