Alatamine

CAS# 41855-33-8

Alatamine

Catalog No. BCN3100----Order now to get a substantial discount!

Product Name & Size Price Stock
Alatamine: 5mg Please Inquire In Stock
Alatamine: 10mg Please Inquire In Stock
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Quality Control of Alatamine

Number of papers citing our products

Chemical structure

Alatamine

3D structure

Chemical Properties of Alatamine

Cas No. 41855-33-8 SDF Download SDF
PubChem ID 102004797 Appearance Powder
Formula C41H45NO18 M.Wt 839.8
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(=O)OCC12C(C(C3C(C14C(C(C(=O)C2OC(=O)C)C(O4)(COC(=O)C5=C(CCC(C(=O)O3)(C)O)N=CC=C5)C)OC(=O)C)(C)O)OC(=O)C6=CC=CC=C6)OC(=O)C
Standard InChIKey WLMGYTNCKLQIDI-BLKXGXPVSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Alatamine

Description1. Alatamine can markedly reduce acute myocardial ischemia (AMI)-induced cardiac injury and cardiac myocyte apoptosis, improve the expression and activity of sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase (SERCA).
TargetsCalcium Channel | ATPase | Bcl-2/Bax

Alatamine Dilution Calculator

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Alatamine Molarity Calculator

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Preparing Stock Solutions of Alatamine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1908 mL 5.9538 mL 11.9076 mL 23.8152 mL 29.769 mL
5 mM 0.2382 mL 1.1908 mL 2.3815 mL 4.763 mL 5.9538 mL
10 mM 0.1191 mL 0.5954 mL 1.1908 mL 2.3815 mL 2.9769 mL
50 mM 0.0238 mL 0.1191 mL 0.2382 mL 0.4763 mL 0.5954 mL
100 mM 0.0119 mL 0.0595 mL 0.1191 mL 0.2382 mL 0.2977 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Alatamine

Cardiac-protective effects and the possible mechanisms of alatamine during acute myocardial ischemia.[Pubmed:26863576]

Can J Physiol Pharmacol. 2016 Apr;94(4):433-40.

Alatamine is a constituent in the extract of a traditional herbal medicine Ramulus euonymi widely used for cardiac protection. However, its precise effects remain unclear. In the present study, we found that Alatamine was able to reduce acute myocardial ischemia (AMI)-induced cardiac dysfunction in a rat model, as reflected by significantly restored electrocardiograms, M-mode echocardiograms, and left ventricular hemodynamics. Also, Nagar Olsen staining revealed that Alatamine markedly reduced AMI-induced cardiac injury and cardiac myocyte apoptosis. TUNEL and caspase-3 activity assay showed that cardiac myocytes underwent significant apoptosis during AMI, and levels of LDH and CK-MB increased in the serum. However, such changes were significantly inhibited by pre-administration of Alatamine. Furthermore, such anti-apoptotic effects of Alatamine was also confirmed in a cardiac myocyte model of isoproterenol (ISO)-induced damage. Mechanistically, it was also found that Alatamine improved the expression and activity of sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase (SERCA), which were inhibited during AMI, promoting contractility and relaxation. Meanwhile, Alatamine decreased Bax and increased Bcl-2 expressions both in vivo and in vitro, therefore inhibiting cardiac myocyte apoptosis and preventing cardiac dysfunction caused by AMI at the cellular level. The present study revealed the beneficial role of Alatamine in cardiac protection and highlighted it as a potential therapeutic reagent for reduction of AMI-induced cardiac injury.

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