Junicedric acid

CAS# 41787-69-3

Junicedric acid

Catalog No. BCN7660----Order now to get a substantial discount!

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Quality Control of Junicedric acid

Number of papers citing our products

Chemical structure

Junicedric acid

3D structure

Chemical Properties of Junicedric acid

Cas No. 41787-69-3 SDF Download SDF
PubChem ID 38347252 Appearance Powder
Formula C20H32O4 M.Wt 336.46
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,4aR,5S,8aR)-5-[(3S)-4-carboxy-3-methylbutyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalene-1-carboxylic acid
SMILES CC(CCC1C(=C)CCC2C1(CCCC2(C)C(=O)O)C)CC(=O)O
Standard InChIKey HPQKNJHVWUWAOR-BWCMQUJESA-N
Standard InChI InChI=1S/C20H32O4/c1-13(12-17(21)22)6-8-15-14(2)7-9-16-19(15,3)10-5-11-20(16,4)18(23)24/h13,15-16H,2,5-12H2,1,3-4H3,(H,21,22)(H,23,24)/t13-,15-,16+,19+,20-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Junicedric acid

The fronds of Dicranopteris linearis or D. ampla.

Biological Activity of Junicedric acid

Description1. Junicedric acid has gastroprotective effects.

Junicedric acid Dilution Calculator

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Junicedric acid Molarity Calculator

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Preparing Stock Solutions of Junicedric acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9721 mL 14.8606 mL 29.7212 mL 59.4424 mL 74.303 mL
5 mM 0.5944 mL 2.9721 mL 5.9442 mL 11.8885 mL 14.8606 mL
10 mM 0.2972 mL 1.4861 mL 2.9721 mL 5.9442 mL 7.4303 mL
50 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.1888 mL 1.4861 mL
100 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.5944 mL 0.743 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Junicedric acid

Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.[Pubmed:21996716]

Molecules. 2011 Oct 13;16(10):8614-28.

New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from Junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.

Synthesis, gastroprotective effect and cytotoxicity of new amino acid diterpene monoamides and diamides.[Pubmed:20966879]

Molecules. 2010 Oct 21;15(10):7378-94.

Following our studies on the gastroprotective effect and cytotoxicity of terpene derivatives, new amides were prepared from the diterpene 8(17)-labden-15,19-dioic acid (Junicedric acid) and its 8(9)-en isomer with C-protected amino acids (amino acid esters). The new compounds were evaluated for their gastroprotective effect in the ethanol/HCl-induced gastric lesions model in mice, as well as for cytotoxicity using the following human cell lines: normal lung fibroblasts (MRC-5), gastric adenocarcinoma cells (AGS) and liver hepatocellular carcinoma (Hep G2). A dose-response experiment showed that at 25 mg/kg the C-15 leucyl and C-15,19-dileucylester amides of Junicedric acid reduced gastric lesions by about 65.6 and 49.6%, respectively, with an effect comparable to lansoprazole at 20 mg/kg (79.3% lesion reduction). The comparison of the gastroprotective effect of 18 new amino acid ester amides was carried out at a single oral dose of 25 mg/kg. Several compounds presented a strong gastroprotective effect, reducing gastric lesions in the 70.9-87.8% range. The diprolyl derivative of Junicedric acid, the most active product of this study (87.8% lesion reduction at 25 mg/kg) presented a cytotoxicity value comparable with that of the reference compound lansoprazole. The structure-activity relationships are discussed.

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