ar-CurcumeneCAS# 4176-06-1 |
- α-Curcumene
Catalog No.:BCX0868
CAS No.:644-30-4
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 4176-06-1 | SDF | Download SDF |
| PubChem ID | 3083834 | Appearance | Liquid |
| Formula | C15H22 | M.Wt | 202.34 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1-methyl-4-[(2S)-6-methylhept-5-en-2-yl]benzene | ||
| SMILES | CC1=CC=C(C=C1)C(C)CCC=C(C)C | ||
| Standard InChIKey | VMYXUZSZMNBRCN-AWEZNQCLSA-N | ||
| Standard InChI | InChI=1S/C15H22/c1-12(2)6-5-7-14(4)15-10-8-13(3)9-11-15/h6,8-11,14H,5,7H2,1-4H3/t14-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. ar-Curcumene is effective as oviposition deterrents against Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus, it can be considered for the development of novel and effective mosquito larvicides. 2. ar-Curcumene has antiinflammatory activity, it could be used as antiinflammatory drugs in respiratory infections. |
| Targets | TNF-α | IL Receptor |
ar-Curcumene Dilution Calculator
ar-Curcumene Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.9422 mL | 24.7109 mL | 49.4218 mL | 98.8435 mL | 123.5544 mL |
| 5 mM | 0.9884 mL | 4.9422 mL | 9.8844 mL | 19.7687 mL | 24.7109 mL |
| 10 mM | 0.4942 mL | 2.4711 mL | 4.9422 mL | 9.8844 mL | 12.3554 mL |
| 50 mM | 0.0988 mL | 0.4942 mL | 0.9884 mL | 1.9769 mL | 2.4711 mL |
| 100 mM | 0.0494 mL | 0.2471 mL | 0.4942 mL | 0.9884 mL | 1.2355 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells.[Pubmed:21698672]
Phytother Res. 2012 Mar;26(3):333-6.
The proinflammatory chemokine interleukin-8 is increased in asthmatic patients. Traditionally, ginger is used as an antiinflammatory drug. An extract and several compounds of Zingiber officinale (ginger) were tested in human bronchial epithelial cells (BEAS-2B cells) with respect to their effect on lipopolysaccharide (LPS)-induced secretion of the proinflammatory chemokine interleukin 8 (IL-8) and RANTES (regulated upon activation, normal T-cell expressed and secreted). An oily extract of ginger rhizome with > 25% total pungent compounds, ginger volatile oil, ar-Curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect. The LPS-induced slight increase of RANTES was reduced by volatile oil, ar-Curcumene and alpha-pinene. There was no effect of LPS on TNF-alpha. Our results suggest that distinct ginger compounds could be used as antiinflammatory drugs in respiratory infections.
Essential oil composition, antioxidant activity and phenolic content of endemic Teucrium alyssifolium Staph. (Lamiaceae).[Pubmed:26918276]
Nat Prod Res. 2016 Oct;30(19):2225-9.
The present study was designed to examine the chemical composition of the essential oil, in vitro antioxidant activity and total phenolic and flavonoid content of extracts from plant parts (leaf, flower and stem) of Teucrium alyssifolium. The principle components of the essential oil were trans-beta-caryophyllene (16.87%), ar-Curcumene (11.43%) and bisabolene (11.06%), representing 39.36% of the oil. The total phenolic contents ranged between 13.99 and 41.54 mg of GAE/g of extract. The concentrations of flavonoids varied from 16.82 to 49.52 mg of Ru/g of extract. Antioxidant activity was determined in vitro using DPPH reagent and expressed as concentration of each extract required to inhibit radical by 50% (IC50) values that ranged from 13.52 to 132.55 mug/ml. Our results have indicated that water extract of T. alyssifolium (part leaf) with a total content of polyphenols (41.54 mg of GAE/g) and an IC50 of 13.52 mug/ml is more antioxidant.
Toxicity of ar-curcumene and epi-beta-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors.[Pubmed:27918946]
Ecotoxicol Environ Saf. 2017 Mar;137:149-157.
Mosquitoes act as vectors of key pathogens and parasites. Plant essential oils have been recognized as important sources of biopesticides, which do not induce resistance and have limited toxic effects on human health and non-target organisms. In this research, we evaluated the larvicidal and oviposition deterrence activity of Hedychium larsenii essential oil (EO) and its major compounds ar-Curcumene and epi-beta-bisabolol. Both molecules showed high toxicity against early third instars of Anopheles stephensi (LC50=10.45 and 14.68microg/ml), Aedes aegypti (LC50=11.24 and 15.83microg/ml) and Culex quinquefasciatus (LC50=12.24 and 17.27microg/ml). In addition, low doses of ar-Curcumene and epi-beta-bisabolol were effective as oviposition deterrents against the three tested mosquito species. Notably, the acute toxicity of H. larsenii oil and its major compounds against the mosquito biocontrol agent Poecilia reticulata was low, with LC50 higher than 1500ppm. Overall, the results from this study revealed that ar-Curcumene and epi-beta-bisabolol from the H. larsenii oil can be considered for the development of novel and effective mosquito larvicides.
