AmbocinCAS# 108044-05-9 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 108044-05-9 | SDF | Download SDF |
| PubChem ID | 5491738 | Appearance | Powder |
| Formula | C26H28O14 | M.Wt | 564.49 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 7-[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]oxy-5-hydroxy-3-(4-hydroxyphenyl)chromen-4-one | ||
| SMILES | C1C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC=C(C4=O)C5=CC=C(C=C5)O)O)O)O)O)O)(CO)O | ||
| Standard InChIKey | UXJMURXRQMFKJC-JEQMPJCPSA-N | ||
| Standard InChI | InChI=1S/C26H28O14/c27-9-26(35)10-38-25(23(26)34)37-8-17-20(31)21(32)22(33)24(40-17)39-13-5-15(29)18-16(6-13)36-7-14(19(18)30)11-1-3-12(28)4-2-11/h1-7,17,20-25,27-29,31-35H,8-10H2/t17-,20-,21+,22-,23+,24-,25-,26-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Ambocin is a natural product from Pueraria mirifica. |
| Structure Identification | Food Science & Biotechnology, 2014, 23(6):1815-1820.Flavonoids from Pueraria mirifica roots and quantitative analysis using HPLC.[Reference: WebLink]
|
Ambocin Dilution Calculator
Ambocin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7715 mL | 8.8576 mL | 17.7151 mL | 35.4302 mL | 44.2878 mL |
| 5 mM | 0.3543 mL | 1.7715 mL | 3.543 mL | 7.086 mL | 8.8576 mL |
| 10 mM | 0.1772 mL | 0.8858 mL | 1.7715 mL | 3.543 mL | 4.4288 mL |
| 50 mM | 0.0354 mL | 0.1772 mL | 0.3543 mL | 0.7086 mL | 0.8858 mL |
| 100 mM | 0.0177 mL | 0.0886 mL | 0.1772 mL | 0.3543 mL | 0.4429 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Bergenin monohydrate
Catalog No.:BCC8132
CAS No.:108032-11-7
- (-)-Noe's Reagent
Catalog No.:BCC8375
CAS No.:108031-79-4
- Withanolide C
Catalog No.:BCN6729
CAS No.:108030-78-0
- H-Tyr-Ome
Catalog No.:BCC3126
CAS No.:1080-06-4
- Phenol
Catalog No.:BCN3800
CAS No.:108-95-2
- Melamine
Catalog No.:BCN7248
CAS No.:108-78-1
- 6-Methyl-5,6-dihydropyran-2-one
Catalog No.:BCN3498
CAS No.:108-54-3
- Resorcinol
Catalog No.:BCN5881
CAS No.:108-46-3
- 2-(Dimethylamino)ethanol
Catalog No.:BCN1798
CAS No.:108-01-0
- Myricananin A
Catalog No.:BCN5880
CAS No.:1079941-35-7
- 9,9-Bis(4-amino-3-methylphenyl)fluorene
Catalog No.:BCC8794
CAS No.:107934-60-1
- Sibiricose A5
Catalog No.:BCN2785
CAS No.:107912-97-0
- Tilmicosin
Catalog No.:BCC4865
CAS No.:108050-54-0
- Roxindole hydrochloride
Catalog No.:BCC7116
CAS No.:108050-82-4
- CP-466722
Catalog No.:BCC3912
CAS No.:1080622-86-1
- KT 5720
Catalog No.:BCC8080
CAS No.:108068-98-0
- α-Terthiophene
Catalog No.:BCN8380
CAS No.:1081-34-1
- 6-(beta-D-glucopyranosyloxy)-Salicylic acid methyl ester
Catalog No.:BCN1631
CAS No.:108124-75-0
- SKF 83566 hydrobromide
Catalog No.:BCC7121
CAS No.:108179-91-5
- TUG 424
Catalog No.:BCC7776
CAS No.:1082058-99-8
- TC-S 7005
Catalog No.:BCC6189
CAS No.:1082739-92-1
- PDE-9 inhibitor
Catalog No.:BCC1842
CAS No.:1082743-70-1
- PF-04447943
Catalog No.:BCC1850
CAS No.:1082744-20-4
- LY2584702
Catalog No.:BCC6369
CAS No.:1082949-67-4
[Absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro].[Pubmed:29171242]
Zhongguo Zhong Yao Za Zhi. 2017 Aug;42(16):3206-3212.
Tongmai formula (TMF) is a drug combination of three components including Puerariae Lobatae Radix [roots of Pueraria lobata], Salviae Miltiorrhizae Radix (roots of Salvia miltiorrhiza) and Chuanxiong Rhizoma (rhizomes of Ligusticum chuanxiong) in a weight ratio of 1ratio1ratio1. The absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro were studied in this paper. The assay isoflavonoid compounds include daidzein, formononetin, 5-hydroxylononin, ononin, daidzin, 3'-methoxypuerarin, genistin, puerarin, formononetin-8-C-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside, formononetin-7-O-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside, lanceolarin, kakkanin, daidzein-7,4'-di-O-beta-D-glucopyranoside, mirificin, 3'-hydroxypuerarin, 3'-methoxydaidzin, formononetin-8-C-beta-D-xylopyranosyl-(1-->6)-O-beta-D-glucopyranoside, genistein-8-C-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside, genistein-7-O-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside (Ambocin), 3'-hydroxymirificin, 6''-O-beta-D-xylosylpuerarin, biochanin A-8-C-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside, 3'-methoxydaidzein-7,4'-di-O-beta-D-glucopyranoside, daidzein-7-O-beta-D-glucopyranosyl-(1-->4)-O-beta-D-glucopyranoside, and daidzein-7-O-alpha-D-glucopyranosyl-(1-->4)-O-beta-D-glucopyranoside. By using human Caco-2 monolayer as an intestinal epithelial cell model in vitro, the permeability of above-mentioned 25 isoflavonoids in TMF were studied from the apical (AP) side to basolateral (BL) side or from the BL side to AP side. The assay compounds were determined by reversed phased high-performance liquid chromatography (HPLC) coupled with UV detector. Transport parameters and apparent permeability coefficients (Papp) were then calculated and and compared with those of propranolol and atenolol, which are the transcellular transport marker and as a control substance for high and poor permeability, respectively. The Papp values of daidzein and formononetin were (2.55+/-0.03) x10(-)(5),(3.06+/-0.01) x10(-)(5) cm*s(-)(1) from AP side to BL side, respectively, and (2.62+/-0.00) x10(-)(5), (2.65+/-0.11) x10(-)(5) cm*s(-)(1) from BL side to AP side, respectively. Under the condition of this experiment, the Papp value was (2.66+/-0.32) x10(-)(5) cm*s(-)(1) for propranolol and (2.34+/-0.10) x10(-)(7) cm*s(-)(1) for atenolol. The Papp values of daidzein and formononetin were at a same magnitude with those of propranolol. And the Papp values of other 23 isoflavonoid compounds were at a same magnitude with those of atenolol. On the other hand, the rats of Papp AP-->BL/Papp BL-->AP of daidzein and formononetin on the influx transport were 0.97 and 1.15, respectively. It can be predicted that daidzein and formononetin can be absorbed across intestinal epithelial cells to go to the body circulation by the passive diffusion mechanism and they were assigned to the well-absorbed compounds. Other 23 isoflavonoid compounds were assigned to the poorly absorbed compounds. Because of the rats of Papp AP-->BL/Papp BL-->AP of 5-hydroxylononin, genistin, lanceolarin, kakkanin, and genistein-7-O-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside were 0.18, 0.28, 0.45, 0.38, 0.49, they may have been involved in the efflux mechanism in Caco-2 cells monolayer model from the BL side to AP side direction.
