TC-S 7005

Potent and selective PLK2 inhibitor CAS# 1082739-92-1

TC-S 7005

Catalog No. BCC6189----Order now to get a substantial discount!

Product Name & Size Price Stock
TC-S 7005: 5mg $150 In Stock
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Chemical structure

TC-S 7005

3D structure

Chemical Properties of TC-S 7005

Cas No. 1082739-92-1 SDF Download SDF
PubChem ID 24971422 Appearance Powder
Formula C21H17N3O3 M.Wt 359.38
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 125 mg/mL (347.82 mM; Need ultrasonic)
Chemical Name 3-(1,3-benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-[1,2]oxazolo[5,4-c]pyridin-5-amine
SMILES CC(C1=CC=CC=C1)NC2=NC=C3C(=C2)C(=NO3)C4=CC5=C(C=C4)OCO5
Standard InChIKey DAAGOCSHXCDWDY-ZDUSSCGKSA-N
Standard InChI InChI=1S/C21H17N3O3/c1-13(14-5-3-2-4-6-14)23-20-10-16-19(11-22-20)27-24-21(16)15-7-8-17-18(9-15)26-12-25-17/h2-11,13H,12H2,1H3,(H,22,23)/t13-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of TC-S 7005

DescriptionPotent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

TC-S 7005 Dilution Calculator

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TC-S 7005 Molarity Calculator

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Preparing Stock Solutions of TC-S 7005

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7826 mL 13.9128 mL 27.8257 mL 55.6514 mL 69.5642 mL
5 mM 0.5565 mL 2.7826 mL 5.5651 mL 11.1303 mL 13.9128 mL
10 mM 0.2783 mL 1.3913 mL 2.7826 mL 5.5651 mL 6.9564 mL
50 mM 0.0557 mL 0.2783 mL 0.5565 mL 1.113 mL 1.3913 mL
100 mM 0.0278 mL 0.1391 mL 0.2783 mL 0.5565 mL 0.6956 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on TC-S 7005

Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.[Pubmed:18790636]

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5186-9.

A series of 2-amino-isoxazolopyridines was designed and synthesized as Polo-like kinase (Plk) inhibitors. Key SAR and crystallographic data are discussed. More advanced analogues inhibit Plk1 with good enzymatic activity and modest cell-based activity. Differential selectivity among the three Plk isoforms is observed.

Description

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively.

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