CitrostadienolCAS# 474-40-8 |
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| Cas No. | 474-40-8 | SDF | Download SDF |
| PubChem ID | 6450181 | Appearance | Powder |
| Formula | C30H50O | M.Wt | 426.72 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3S,4S,5S,9R,10S,13R,14R,17R)-4,10,13-trimethyl-17-[(Z)-5-propan-2-ylhept-5-en-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | ||
| SMILES | CC=C(CCC(C)C1CCC2C1(CCC3C2=CCC4C3(CCC(C4C)O)C)C)C(C)C | ||
| Standard InChIKey | LPZCCMIISIBREI-LMIGCCGUSA-N | ||
| Standard InChI | InChI=1S/C30H50O/c1-8-22(19(2)3)10-9-20(4)24-13-14-26-23-11-12-25-21(5)28(31)16-18-30(25,7)27(23)15-17-29(24,26)6/h8,11,19-21,24-28,31H,9-10,12-18H2,1-7H3/b22-8-/t20?,21-,24+,25-,26-,27-,28-,29+,30-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Citrostadienol shows cytotoxic activity against B16F10 melanoma cells. |
Citrostadienol Dilution Calculator
Citrostadienol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3435 mL | 11.7173 mL | 23.4346 mL | 46.8691 mL | 58.5864 mL |
| 5 mM | 0.4687 mL | 2.3435 mL | 4.6869 mL | 9.3738 mL | 11.7173 mL |
| 10 mM | 0.2343 mL | 1.1717 mL | 2.3435 mL | 4.6869 mL | 5.8586 mL |
| 50 mM | 0.0469 mL | 0.2343 mL | 0.4687 mL | 0.9374 mL | 1.1717 mL |
| 100 mM | 0.0234 mL | 0.1172 mL | 0.2343 mL | 0.4687 mL | 0.5859 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex.[Pubmed:24008110]
J Ethnopharmacol. 2013 Oct 28;150(1):263-9.
ETHNOPHARMACOLOGICAL RELEVANCE: Synadenium grantii Hook f. has traditionally been used to treat various neoplastic diseases in southern Brazil. AIM OF STUDY: Evaluation of the antitumoural potential of Synadenium grantii latex against B16F10 melanoma cell line using in vitro and in vivo models, as well as a phytochemical study of the latex. MATERIALS AND METHODS: The in vitro antitumoural activity was performed using MTT and trypan blue assays with different latex concentrations (1.7 microg-7.0 microg/well and 1.22 mg-4.88 mg/well). Flow cytometry was used to determine the progression of the cell cycle. The in vivo activity was performed by subcutaneously injecting melanoma cells in the dorsum of C57BL6 mice, followed by treating the mice with a popular form of use of the latex (garrafada) administered orally. After sacrificing the animals, histological analysis of the organs was performed by hematoxylin-eosin staining. The phytochemical study of the latex was performed by NMR and chromatographic procedures and the extracts and isolated substances were evaluated by IR, 1D and 2D NMR analysis. RESULTS: The Synadenium grantii latex exhibited decreased cell viability of the melanoma line in a concentration and time-dependent manner, and also cell cycle arrest in the S-G2/M phase. The latex caused a 40% reduction in the volume of tumours of the mice with melanomas. Histological examination of the organs of these animals showed no differences between groups. The phytochemical investigation resulted in the isolation and identification of triterpene euphol and the steroid Citrostadienol, which were tested against the strain of melanoma. Euphol showed no antitumoural activity, while the steroid Citrostadienol showed reduced cytotoxic activity. CONCLUSION: The Synadenium grantii latex presented in vitro and in vivo cytotoxic effects with antitumoural activity against B16F10 melanoma cells.
Sterols and squalene in apricot (Prunus armeniaca L.) kernel oils: the variety as a key factor.[Pubmed:26745662]
Nat Prod Res. 2017 Jan;31(1):84-88.
The profile of sterols and squalene content in oils recovered from the kernels of 15 apricot (Prunus armeniaca L.) varieties were investigated. Nine sterols (campesterol, beta-sitosterol, Delta5-avenasterol, 24-methylene-cycloartanol, cholesterol, gramisterol, Delta7-stigmasterol, Delta7-avenasterol and Citrostadienol) were identified in apricot kernel oils. The beta-sitosterol was the predominant sterol in each cultivar and consisted of 76-86% of the total detected sterols. The content of total sterols and squalene were significantly affected by the variety and ranged between 215.7-973.6 and 12.6-43.9 mg/100 g of oil, respectively.
