Forskolin G

CAS# 473981-11-2

Forskolin G

2D Structure

Catalog No. BCN5527----Order now to get a substantial discount!

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Forskolin G: 5mg $903 In Stock
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3D structure

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Forskolin G

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Chemical Properties of Forskolin G

Cas No. 473981-11-2 SDF Download SDF
PubChem ID 12967001 Appearance Powder
Formula C24H36O7 M.Wt 436.6
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(3R,4aS,5S,6S,6aS,10S,10aS,10bR)-5-acetyloxy-3-ethenyl-10-hydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-2,5,6,6a,8,9,10,10b-octahydrobenzo[f]chromen-6-yl] acetate
SMILES CC(=O)OC1C2C(CCC(C2(C3C(=O)CC(OC3(C1OC(=O)C)C)(C)C=C)C)O)(C)C
Standard InChIKey KLAOOPRSOQWAOS-NHBJGEBFSA-N
Standard InChI InChI=1S/C24H36O7/c1-9-22(6)12-15(27)18-23(7)16(28)10-11-21(4,5)19(23)17(29-13(2)25)20(30-14(3)26)24(18,8)31-22/h9,16-20,28H,1,10-12H2,2-8H3/t16-,17-,18+,19-,20-,22-,23+,24-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Forskolin G

The herbs of Coleus forskohlii

Biological Activity of Forskolin G

DescriptionForskolin is known to elevate intracellular cAMP levels.

Protocol of Forskolin G

Cell Research

Reversal of doxorubicin resistance by hydrophobic, but not hydrophilic, forskolins.[Reference: WebLink]

Molecular Pharmacology, 1992, 40(6):960-964.

The plant diterpene forskolin reverses acquired resistance to doxorubicin in variants of the murine sarcoma S180 cell line.
METHODS AND RESULTS:
Because forskolin is known to elevate intracellular cAMP levels, investigations were performed to determine whether this reversal of resistance resulted from effects on signal transduction. Two analogues of forskolin(Forskolin G), dideoxyforskolin, which does not elevate cAMP, and a water-soluble analogue, were also investigated. Although all three diterpenes elevated levels of either cAMP or protein kinase C, these effects were not consistently associated with reversal of doxorubicin resistance. Likewise, all three diterpenes were capable of displacing [3H]azidopine from P-glycoprotein, but reversal of doxorubicin resistance was observed only with forskolin and dideoxyforskolin, suggesting that binding to P-glycoprotein may be a necessary, but not sufficient, condition for reversing doxorubicin resistance.
CONCLUSIONS:
The hydrophobicity of the compounds appeared to be the single factor most consistently related to reversal of doxorubicin resistance in this cell system, with the hydrophilic compound water-soluble forskolin failing to produce this result, even at concentrations 10-fold higher than effective concentrations of the hydrophobic diterpenes.

Forskolin G Dilution Calculator

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Forskolin G Molarity Calculator

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Preparing Stock Solutions of Forskolin G

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2904 mL 11.4521 mL 22.9043 mL 45.8085 mL 57.2607 mL
5 mM 0.4581 mL 2.2904 mL 4.5809 mL 9.1617 mL 11.4521 mL
10 mM 0.229 mL 1.1452 mL 2.2904 mL 4.5809 mL 5.7261 mL
50 mM 0.0458 mL 0.229 mL 0.4581 mL 0.9162 mL 1.1452 mL
100 mM 0.0229 mL 0.1145 mL 0.229 mL 0.4581 mL 0.5726 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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