Cyclo(Tyr-Phe)

CAS# 5147-17-1

Cyclo(Tyr-Phe)

Catalog No. BCN2423----Order now to get a substantial discount!

Product Name & Size Price Stock
Cyclo(Tyr-Phe): 5mg $196 In Stock
Cyclo(Tyr-Phe): 10mg Please Inquire In Stock
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Cyclo(Tyr-Phe): 200mg Please Inquire Please Inquire
Cyclo(Tyr-Phe): 500mg Please Inquire Please Inquire
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Quality Control of Cyclo(Tyr-Phe)

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Chemical structure

Cyclo(Tyr-Phe)

3D structure

Chemical Properties of Cyclo(Tyr-Phe)

Cas No. 5147-17-1 SDF Download SDF
PubChem ID 44198062 Appearance Powder
Formula C18H18N2O3 M.Wt 310.35
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-benzyl-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione
SMILES C1=CC=C(C=C1)CC2C(=O)NC(C(=O)N2)CC3=CC=C(C=C3)O
Standard InChIKey GRWVBLRIPRGGPD-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H18N2O3/c21-14-8-6-13(7-9-14)11-16-18(23)19-15(17(22)20-16)10-12-4-2-1-3-5-12/h1-9,15-16,21H,10-11H2,(H,19,23)(H,20,22)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cyclo(Tyr-Phe)

The Brevibacillus borstelensis

Biological Activity of Cyclo(Tyr-Phe)

DescriptionCyclo-(Phe-Tyr) shows anticoagulant activities.
In vitro

Anticoagulant activity of cyclic dipeptides from Sparganii Rhizome[Reference: WebLink]

Chinese Traditional Patent Medicine, 2015,37 (1): 34-9.

To study the in vitro anticoagulant activity of cyclodipeptide( cyclo-( Tyr-Leu),cyclo-( PhePhe) and cyclo-( Phe-Tyr)) isolated from Sparganium stoloniferum Buch.-Ham.
METHODS AND RESULTS:
The special kits were used to measure anticoagulant activity with platelet poor plasma collected from abdominal aorta of male SD rats,including prothrombin time( PT),activated partial thromboplastin time( APTT) and thrombin time( TT).PT,APTT,TT were prolonged by the addition of cyclo-( Tyr-Leu),cyclo-( Phe-Phe) and Cyclo(Tyr-Phe). The former two presented no dose-effect relationship but the latter did.
CONCLUSIONS:
Of three cyclodipeptides from S. stoloniferum,all the three show anticoagulant activities with cyclo-( Phe-Tyr) being by far the most effective.

Cyclo(Tyr-Phe) Dilution Calculator

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Cyclo(Tyr-Phe) Molarity Calculator

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Preparing Stock Solutions of Cyclo(Tyr-Phe)

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2222 mL 16.1108 mL 32.2217 mL 64.4434 mL 80.5542 mL
5 mM 0.6444 mL 3.2222 mL 6.4443 mL 12.8887 mL 16.1108 mL
10 mM 0.3222 mL 1.6111 mL 3.2222 mL 6.4443 mL 8.0554 mL
50 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.2889 mL 1.6111 mL
100 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.6444 mL 0.8055 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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