DehydroheliobuphthalminCAS# 103001-05-4 |
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| Cas No. | 103001-05-4 | SDF | Download SDF |
| PubChem ID | 91884890 | Appearance | Powder |
| Formula | C22H20O8 | M.Wt | 412.4 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | dimethyl (3E)-2-(1,3-benzodioxol-5-ylmethyl)-3-(1,3-benzodioxol-5-ylmethylidene)butanedioate | ||
| SMILES | COC(=O)C(CC1=CC2=C(C=C1)OCO2)C(=CC3=CC4=C(C=C3)OCO4)C(=O)OC | ||
| Standard InChIKey | MHPJAZYITXHVOI-VIZOYTHASA-N | ||
| Standard InChI | InChI=1S/C22H20O8/c1-25-21(23)15(7-13-3-5-17-19(9-13)29-11-27-17)16(22(24)26-2)8-14-4-6-18-20(10-14)30-12-28-18/h3-7,9-10,16H,8,11-12H2,1-2H3/b15-7+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The leaves of Platycladus orientalis
| Description | 1. Dehydroheliobuphthalmin has significant neuroprotective activities against glutamate- induced neurotoxicity. |
Dehydroheliobuphthalmin Dilution Calculator
Dehydroheliobuphthalmin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4248 mL | 12.1242 mL | 24.2483 mL | 48.4966 mL | 60.6208 mL |
| 5 mM | 0.485 mL | 2.4248 mL | 4.8497 mL | 9.6993 mL | 12.1242 mL |
| 10 mM | 0.2425 mL | 1.2124 mL | 2.4248 mL | 4.8497 mL | 6.0621 mL |
| 50 mM | 0.0485 mL | 0.2425 mL | 0.485 mL | 0.9699 mL | 1.2124 mL |
| 100 mM | 0.0242 mL | 0.1212 mL | 0.2425 mL | 0.485 mL | 0.6062 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.[Pubmed:25479041]
J Nat Prod. 2014 Dec 26;77(12):2641-50.
Two new arylbenzofuran-type neolignans, 1"-dehydroegonol 3"-methyl ether (1) and egonol 3"-methyl ether (2), and four known lignan derivatives, namely, helioxanthin (3), (7E)-7,8-Dehydroheliobuphthalmin (4), heliobuphthalmin (5), and 7-acetoxyhinokinin (6), were isolated from a chloroform-soluble partition of the methanol extract of the fresh roots of Heliopsis helianthoides var. scabra. These six compounds were evaluated in vitro in terms of their ability to inhibit the various steps involved in brain tumor metastasis formation. Compounds 3 and 4 inhibited the migration of both melanoma and brain endothelial cells, and 3 also reduced the adhesion of melanoma cells to the brain endothelium. Furthermore, 3 and 4 additionally enhanced the barrier function of the blood-brain barrier and the expression of the tight junction protein ZO-1 at the junctions of the endothelial cells. These findings suggest that 3 and 4 may have the potential to interfere with different steps of brain metastasis formation and to enhance the barrier function of cerebral endothelial cells.
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