2-Amino-6-chloropurineCAS# 10310-21-1 |
Quality Control & MSDS
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| Cas No. | 10310-21-1 | SDF | Download SDF |
| PubChem ID | 5360349 | Appearance | Powder |
| Formula | C5H4ClN5 | M.Wt | 169.6 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 6-chloro-7H-purin-2-amine | ||
| SMILES | C1=NC2=C(N1)C(=NC(=N2)N)Cl | ||
| Standard InChIKey | RYYIULNRIVUMTQ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
2-Amino-6-chloropurine Dilution Calculator
2-Amino-6-chloropurine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.8962 mL | 29.4811 mL | 58.9623 mL | 117.9245 mL | 147.4057 mL |
| 5 mM | 1.1792 mL | 5.8962 mL | 11.7925 mL | 23.5849 mL | 29.4811 mL |
| 10 mM | 0.5896 mL | 2.9481 mL | 5.8962 mL | 11.7925 mL | 14.7406 mL |
| 50 mM | 0.1179 mL | 0.5896 mL | 1.1792 mL | 2.3585 mL | 2.9481 mL |
| 100 mM | 0.059 mL | 0.2948 mL | 0.5896 mL | 1.1792 mL | 1.4741 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.[Pubmed:22417649]
Bioorg Med Chem. 2012 Apr 15;20(8):2669-74.
Synthesis of 6-deoxycyclopropavir (10), a prodrug of cyclopropavir (1) and its in vitro and in vivo antiviral activity is described. 2-Amino-6-chloropurine methylenecyclopropane 13 was transformed to its 6-iodo derivative 14 which was reduced to prodrug 10. It is converted to cyclopropavir (1) by the action of xanthine oxidase and this reaction can also occur in vivo. Compound 10 lacked significant in vitro activity against human cytomegalovirus (HCMV), human herpes virus 1 and 2 (HSV-1 and HSV-2), human immunodeficiency virus type 1 (HIV-1), human hepatitis B virus (HBV), Epstein-Barr virus (EBV), vaccinia virus and cowpox virus. In contrast, prodrug 10 given orally was as active as cyclopropavir (1) reported previously [Kern, E. R.; Bidanset, D. J.; Hartline, C. B.; Yan, Z.; Zemlicka, J.; Quenelle, D. C. et al. Antimicrob. Agents Chemother. 2004, 48, 4745] against murine cytomegalovirus (MCMV) infection in mice and against HCMV in severe combined immunodeficient (SCID) mice.
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