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EHNA hydrochloride

CAS# 81408-49-3

EHNA hydrochloride

Catalog No. BCC6996----Order now to get a substantial discount!

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EHNA hydrochloride: 5mg $58 In Stock
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Chemical structure

EHNA hydrochloride

3D structure

Chemical Properties of EHNA hydrochloride

Cas No. 81408-49-3 SDF Download SDF
PubChem ID 11957547 Appearance Powder
Formula C14H24ClN5O M.Wt 313.83
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO > 10 mM
Chemical Name (2R,3S)-3-(6-aminopurin-9-yl)nonan-2-ol;hydrochloride
SMILES CCCCCCC(C(C)O)N1C=NC2=C1N=CN=C2N.Cl
Standard InChIKey VVDXNJRUNJMYOZ-DHXVBOOMSA-N
Standard InChI InChI=1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m1./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

EHNA hydrochloride Dilution Calculator

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EHNA hydrochloride Molarity Calculator

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Preparing Stock Solutions of EHNA hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1864 mL 15.9322 mL 31.8644 mL 63.7288 mL 79.661 mL
5 mM 0.6373 mL 3.1864 mL 6.3729 mL 12.7458 mL 15.9322 mL
10 mM 0.3186 mL 1.5932 mL 3.1864 mL 6.3729 mL 7.9661 mL
50 mM 0.0637 mL 0.3186 mL 0.6373 mL 1.2746 mL 1.5932 mL
100 mM 0.0319 mL 0.1593 mL 0.3186 mL 0.6373 mL 0.7966 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on EHNA hydrochloride

PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesis.[Pubmed:25330380]

PLoS One. 2014 Oct 16;9(10):e109862.

Our previous studies demonstrated that the topical application of caffeine is a potent inhibitor of UVB-induced carcinogenesis and selectively increases apoptosis in tumors but not in non-tumor areas of the epidermis in mice that are at a high risk for developing skin cancer. While this effect is mainly through a p53 independent pathway, the mechanism by which caffeine inhibits skin tumor formation has not been fully elucidated. Since caffeine is a non-specific phosphodiesterase inhibitor, we investigated the effects of several PDE inhibitors on the formation of sunburn cells in mouse skin after an acute exposure to ultraviolet light B (UVB). The topical application of a PDE2 inhibitor, erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride (EHNA hydrochloride), stimulated epidermal apoptosis compared to control (P<0.01) and to a greater extent than caffeine whereas a PDE4 inhibitor attenuated the epidermal apoptosis compared to control (P<0.01). Since PDE2 hydrolyzes cyclic nucleotides, mainly cGMP, the effects of EHNA hydrochloride on epidermal apoptosis following UVB exposure may be mediated, in part, by increased cGMP signaling. Data demonstrated that the topical application of dibutyryl cGMP stimulated epidermal apoptosis (P<0.01) following an acute exposure to UVB. Treating UVB-pretreated mice topically with 3.1 micromole or 0.8 micromole of EHNA hydrochloride attenuated tumor formation to a greater extent than treating with 6.2 micromole caffeine when these compounds were applied once a day, five days a week for 18 weeks. These observations suggest a novel role for PDE2 in UVB-induced tumorigenesis and that PDE2 inhibitors that mediate cGMP signaling may be useful for the prevention and treatment of skin cancer.

Susceptibility of Trypanosoma evansi to cordycepin.[Pubmed:21620640]

Biomed Pharmacother. 2011 Jun;65(3):220-3.

Drugs, which are effective during the early stage of trypanosomosis, but poorly penetrate the blood-brain barrier, are ineffective when parasites reach the brain and cause encephalitis. In order to seek alternative treatments, the aim of this study was to test the susceptibility of T. evansi to cordycepin in vitro and in rats experimentally infected. In vitro, a significant decrease (P<0.01) in live trypanosomes in the concentrations of 5.0 and 10 mug/mL was observed 1 hour after the beginning of the study, as well as at 3, 6, 9 and 12 hours in all concentrations compared to control. Although no curative effects were observed in the in vivo assay in the majority of groups, the drug was able to maintain parasitemia at low levels, therefore increasing the longevity of rats when compared to positive control group. Rats that received cordycepin alone or in combination with adenosine deaminase inhibitor (ADA: EHNA hydrochloride), did not show trypomastigote forms of the parasite in the bloodstream 24 hours after the administration. These animals remained negative in blood smears on average for 8 days, but thereafter had a recurrence of parasitemia. Among all the infected animals, only three rats in the group treated with the combination of cordycepin (2 mg/kg) and EHNA hydrochloride (2 mg/kg) remained negative during the experimental period. The curative efficacy of 42.5% was confirmed by PCR using T. evansi-specific primers. Thus, we conclude that cordycepin has biological effect against T. evansi, as previously reported in infections by T. brucei, T. cruzi and Leishmania sp. The treatment with cordycepin, when protected by an inhibitor of ADA, can prolong the survival of T. evansi-infected rats and provide curative efficacy.

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