alpha-DihydroartemisininCAS# 81496-81-3 |
- Dihydroartemisinin
Catalog No.:BCN6264
CAS No.:71939-50-9
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| Cas No. | 81496-81-3 | SDF | Download SDF |
| PubChem ID | 179336 | Appearance | Cryst. |
| Formula | C15H24O5 | M.Wt | 284.34 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C | ||
| Standard InChIKey | BJDCWCLMFKKGEE-FTRRWEDQSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Dihydroartemisinin is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs, is recommended as the first-line anti-malarial drug with low toxicity. Dihydroartemisinin possesses promising anticancer activities and induce cancer cell death through apoptotic pathways. |
| Targets | Antifection |
| Structure Identification | J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 1;875(1):180-91.On-column epimerization of dihydroartemisinin: an effective analytical approach to overcome the shortcomings of the International Pharmacopoeia monograph.[Pubmed: 18617445]We developed a cryo-HPLC/UV method for the simultaneous determination of artemisinin (1), alpha-Dihydroartemisinin (2alpha), beta-dihydroartemisinin (2beta), and a ubiquitous thermal decomposition product of 2 (designated as diketoaldehyde, 3), starting from the International Pharmacopoeia monograph on dihydroartemisinin. The method takes for the first time the on-column epimerization process of 2 into consideration. Chromatographic separation was obtained under reversed-phase conditions on a Symmetry C18 column (3.5 microm particle size) with a mobile phase consisting of acetonitrile-water 60:40 (v/v), delivered at 0.60-1.00 ml/min flow-rates, with ultraviolet detection at low wavelength (lambda = 210 nm). |
alpha-Dihydroartemisinin Dilution Calculator
alpha-Dihydroartemisinin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5169 mL | 17.5846 mL | 35.1692 mL | 70.3383 mL | 87.9229 mL |
| 5 mM | 0.7034 mL | 3.5169 mL | 7.0338 mL | 14.0677 mL | 17.5846 mL |
| 10 mM | 0.3517 mL | 1.7585 mL | 3.5169 mL | 7.0338 mL | 8.7923 mL |
| 50 mM | 0.0703 mL | 0.3517 mL | 0.7034 mL | 1.4068 mL | 1.7585 mL |
| 100 mM | 0.0352 mL | 0.1758 mL | 0.3517 mL | 0.7034 mL | 0.8792 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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On-column epimerization of dihydroartemisinin: an effective analytical approach to overcome the shortcomings of the International Pharmacopoeia monograph.[Pubmed:18617445]
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 1;875(1):180-91.
We developed a cryo-HPLC/UV method for the simultaneous determination of artemisinin (1), alpha-Dihydroartemisinin (2alpha), beta-dihydroartemisinin (2beta), and a ubiquitous thermal decomposition product of 2 (designated as diketoaldehyde, 3), starting from the International Pharmacopoeia monograph on dihydroartemisinin. The method takes for the first time the on-column epimerization process of 2 into consideration. Chromatographic separation was obtained under reversed-phase conditions on a Symmetry C18 column (3.5 microm particle size) with a mobile phase consisting of acetonitrile-water 60:40 (v/v), delivered at 0.60-1.00 ml/min flow-rates, with ultraviolet detection at low wavelength (lambda = 210 nm). Low temperatures (T = 0-10 degrees C) were selected on the grounds of a diastereoselective dynamic HPLC (DHPLC) study performed at different temperatures, aimed at identifying the best experimental conditions capable of minimizing the on-column interconversion process.
