(-)-PinoresinolCAS# 81446-29-9 |
- (-)-Epipinoresinol
Catalog No.:BCN3377
CAS No.:10061-38-8
- (+)-Epipinoresinol
Catalog No.:BCN3255
CAS No.:24404-50-0
- Pinoresinol
Catalog No.:BCN5591
CAS No.:487-36-5
- (±)-Pinoresinol
Catalog No.:BCN9179
CAS No.:4263-88-1
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 81446-29-9 | SDF | Download SDF |
PubChem ID | 12309636 | Appearance | Powder |
Formula | C20H22O6 | M.Wt | 358.4 |
Type of Compound | Lignans | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 4-[(3R,3aS,6R,6aS)-6-(4-hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol | ||
SMILES | COC1=C(C=CC(=C1)C2C3COC(C3CO2)C4=CC(=C(C=C4)O)OC)O | ||
Standard InChIKey | HGXBRUKMWQGOIE-NSMLZSOPSA-N | ||
Standard InChI | InChI=1S/C20H22O6/c1-23-17-7-11(3-5-15(17)21)19-13-9-26-20(14(13)10-25-19)12-4-6-16(22)18(8-12)24-2/h3-8,13-14,19-22H,9-10H2,1-2H3/t13-,14-,19+,20+/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Pinoresinol (PIN)can ameliorate CCl4-induced acute liver injury, and this protection is likely due to anti-oxidative activity and down-regulation of inflammatory mediators through inhibition of NF-kappaB and AP-1. 2. (+)-Pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans. 3. Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels, suggests that this could be a mechanism by which PIN reduces proliferation and induces differentiation on HL60 cells. |
Targets | TNF-α | COX | NF-kB | NOS | AP-1 | JNK | CDK | p21 |
(-)-Pinoresinol Dilution Calculator
(-)-Pinoresinol Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.7902 mL | 13.9509 mL | 27.9018 mL | 55.8036 mL | 69.7545 mL |
5 mM | 0.558 mL | 2.7902 mL | 5.5804 mL | 11.1607 mL | 13.9509 mL |
10 mM | 0.279 mL | 1.3951 mL | 2.7902 mL | 5.5804 mL | 6.9754 mL |
50 mM | 0.0558 mL | 0.279 mL | 0.558 mL | 1.1161 mL | 1.3951 mL |
100 mM | 0.0279 mL | 0.1395 mL | 0.279 mL | 0.558 mL | 0.6975 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 8-Hydroxypinoresinol
Catalog No.:BCN3389
CAS No.:81426-17-7
- 8-Acetoxypinoresinol
Catalog No.:BCN2161
CAS No.:81426-14-4
- Sanggenone D
Catalog No.:BCN1194
CAS No.:81422-93-7
- Cabergoline
Catalog No.:BCC5276
CAS No.:81409-90-7
- EHNA hydrochloride
Catalog No.:BCC6996
CAS No.:81408-49-3
- Alfuzosin
Catalog No.:BCC4080
CAS No.:81403-80-7
- Alfuzosin HCl
Catalog No.:BCC2494
CAS No.:81403-68-1
- Acetylvalerenolic acid
Catalog No.:BCC8112
CAS No.:81397-67-3
- Fmoc-His(Boc)-OH.CHA
Catalog No.:BCC2595
CAS No.:81379-52-4
- Seglitide
Catalog No.:BCC7191
CAS No.:81377-02-8
- Momordicoside G
Catalog No.:BCN4349
CAS No.:81371-54-2
- Momordicoside K
Catalog No.:BCN3272
CAS No.:81348-84-7
- Taxagifine
Catalog No.:BCN6949
CAS No.:81489-69-2
- 1-Hydroxypinoresinol 1-O-glucoside
Catalog No.:BCN7019
CAS No.:81495-71-8
- alpha-Dihydroartemisinin
Catalog No.:BCN2627
CAS No.:81496-81-3
- Nafamostat
Catalog No.:BCC4187
CAS No.:81525-10-2
- Forsythoside B
Catalog No.:BCN1205
CAS No.:81525-13-5
- 2-Pentadecenedioic acid
Catalog No.:BCN3666
CAS No.:81588-35-4
- Neuromedin C (porcine)
Catalog No.:BCC5832
CAS No.:81608-30-2
- Withaperuvin C
Catalog No.:BCN6727
CAS No.:81644-34-0
- Canusesnol A
Catalog No.:BCN4350
CAS No.:816456-90-3
- 3-Dehydro-15-deoxoeucosterol
Catalog No.:BCN4351
CAS No.:81678-46-8
- 18-Beta-hydroxy-3-epi-alpha-yohimbine
Catalog No.:BCN3518
CAS No.:81703-06-2
- Rehmannioside A
Catalog No.:BCN2885
CAS No.:81720-05-0
Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice.[Pubmed:20093790]
J Pharmacol Sci. 2010;112(1):105-12.
Forsythiae Fructus is known to have diuretic, anti-bacterial, and anti-inflammatory activities. This study examined the hepatoprotective effects of pinoresinol, a lignan isolated from Forsythiae Fructus, against carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with vehicle or pinoresinol (25, 50, 100, and 200 mg/kg) 30 min before and 2 h after CCl4 (20 microl/kg) injection. In the vehicle-treated CCl(4 )group, serum aminotransferase activities were significantly increased 24 h after CCl4 injection, and these increases were attenuated by pinoresinol at all doses. Hepatic glutathione contents were significantly decreased and lipid peroxidation was increased after CCl4 treatment. These changes were attenuated by 50 and 100 mg/kg of pinoresinol. The levels of protein and mRNA expression of inflammatory mediators, including tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclooxygenase-2, were significantly increased after CCl4 injection; and these increases were attenuated by pinoresinol. Nuclear translocation of nuclear factor-kappaB (NF-kappaB) and phosphorylation of c-Jun, one of the components of activating protein 1 (AP-1), were inhibited by pinoresinol. Our results suggest that pinoresinol ameliorates CCl4)-induced acute liver injury, and this protection is likely due to anti-oxidative activity and down-regulation of inflammatory mediators through inhibition of NF-kappaB and AP-1.
Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii.[Pubmed:20657496]
Molecules. 2010 May 14;15(5):3507-16.
In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments. Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.