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Lucidenic acid SP1

CAS# 364622-33-3

Lucidenic acid SP1

Catalog No. BCN7969----Order now to get a substantial discount!

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Quality Control of Lucidenic acid SP1

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Chemical structure

Lucidenic acid SP1

3D structure

Chemical Properties of Lucidenic acid SP1

Cas No. 364622-33-3 SDF Download SDF
PubChem ID 21592283 Appearance Powder
Formula C27H40O6 M.Wt 460.60
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (4R)-4-[(3S,5R,7S,10S,13R,14R,17R)-3,7-dihydroxy-4,4,10,13,14-pentamethyl-11,15-dioxo-2,3,5,6,7,12,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
SMILES CC(CCC(=O)O)C1CC(=O)C2(C1(CC(=O)C3=C2C(CC4C3(CCC(C4(C)C)O)C)O)C)C
Standard InChIKey YBGBNHHXOJXFNM-UQCMLMITSA-N
Standard InChI InChI=1S/C27H40O6/c1-14(7-8-21(32)33)15-11-20(31)27(6)23-16(28)12-18-24(2,3)19(30)9-10-25(18,4)22(23)17(29)13-26(15,27)5/h14-16,18-19,28,30H,7-13H2,1-6H3,(H,32,33)/t14-,15-,16+,18+,19+,25+,26-,27+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lucidenic acid SP1

The fruit body of Ganoderma lucidum

Biological Activity of Lucidenic acid SP1

In vitro

Anticomplement activity of terpenoids from the spores of Ganoderma lucidum.[Pubmed: 11745016]

Planta Med. 2001 Dec;67(9):811-4.

A new lanostane-type terpenoid, Lucidenic acid SP1 (1), was isolated from a CHCl(3)-soluble fraction of Ganoderma lucidum spores together with four other known compounds (2 - 5).
METHODS AND RESULTS:
The structure of Lucidenic acid SP1 was determined to be 3 beta,7 beta-dihydroxy-4,4,14 alpha-trimethyl-11,15-dioxo-5 alpha-chol-8-en-24-oic acid by spectroscopic means including 2D-NMR. Twelve triterpenes (1-12) isolated from G. lucidum spores were investigated in vitro for their anticomplementary activity.
CONCLUSIONS:
Compounds 1 - 5 were inactive, whereas ganoderiol F (8), ganodermanondiol (9) and ganodermanontriol (10) showed a strong anticomplement activity against the classical pathway (CP) of the complement system with IC(50) values of 4.8, 41.7, and 17.2 microM, respectively. The potency of these triterpene alcohols (8-10) in inhibiting CP activity was improved when the number of hydroxymethyl groups on the side chain moiety is increased. On the other hand, the ganoderic acids 1-7, which contain a carboxyl group in the side chain, and lucidumols A and B (11, 12) had little activity on this system.

Lucidenic acid SP1 Dilution Calculator

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Lucidenic acid SP1 Molarity Calculator

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Preparing Stock Solutions of Lucidenic acid SP1

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1711 mL 10.8554 mL 21.7108 mL 43.4216 mL 54.277 mL
5 mM 0.4342 mL 2.1711 mL 4.3422 mL 8.6843 mL 10.8554 mL
10 mM 0.2171 mL 1.0855 mL 2.1711 mL 4.3422 mL 5.4277 mL
50 mM 0.0434 mL 0.2171 mL 0.4342 mL 0.8684 mL 1.0855 mL
100 mM 0.0217 mL 0.1086 mL 0.2171 mL 0.4342 mL 0.5428 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lucidenic acid SP1

Anticomplement activity of terpenoids from the spores of Ganoderma lucidum.[Pubmed:11745016]

Planta Med. 2001 Dec;67(9):811-4.

A new lanostane-type terpenoid, Lucidenic acid SP1 (1), was isolated from a CHCl(3)-soluble fraction of Ganoderma lucidum spores together with four other known compounds (2 - 5). The structure of Lucidenic acid SP1 was determined to be 3 beta,7 beta-dihydroxy-4,4,14 alpha-trimethyl-11,15-dioxo-5 alpha-chol-8-en-24-oic acid by spectroscopic means including 2D-NMR. Twelve triterpenes (1-12) isolated from G. lucidum spores were investigated in vitro for their anticomplementary activity. Compounds 1 - 5 were inactive, whereas ganoderiol F (8), ganodermanondiol (9) and ganodermanontriol (10) showed a strong anticomplement activity against the classical pathway (CP) of the complement system with IC(50) values of 4.8, 41.7, and 17.2 microM, respectively. The potency of these triterpene alcohols (8-10) in inhibiting CP activity was improved when the number of hydroxymethyl groups on the side chain moiety is increased. On the other hand, the ganoderic acids 1-7, which contain a carboxyl group in the side chain, and lucidumols A and B (11, 12) had little activity on this system.

Description

Lucidenic acid LM1 is a natural triterpenoid isolated from Ganoderma lucidum.

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