MoslosooflavoneCAS# 3570-62-5 |
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| Cas No. | 3570-62-5 | SDF | Download SDF |
| PubChem ID | 188316 | Appearance | Light yellow powder |
| Formula | C17H14O5 | M.Wt | 298.3 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Synonyms | 7,8-Dimethoxynorwogonin; 5-Hydroxy 7,8-dimethoxyflavone; Moslosooflavone; Wogonin 7-methyl ether | ||
| Solubility | Soluble in methan | ||
| Chemical Name | 5-hydroxy-7,8-dimethoxy-2-phenylchromen-4-one | ||
| SMILES | COC1=C(C2=C(C(=C1)O)C(=O)C=C(O2)C3=CC=CC=C3)OC | ||
| Standard InChIKey | IHLSBQVBFDTNTC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H14O5/c1-20-14-9-12(19)15-11(18)8-13(10-6-4-3-5-7-10)22-17(15)16(14)21-2/h3-9,19H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Moslosooflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. Moslosooflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages. |
| Targets | NF-kB | IFN-γ | IL Receptor | NO | TNF-α |
| In vitro | Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition.[Pubmed: 20085279]J Agric Food Chem. 2010 Feb 24;58(4):2505-12.Previous studies showed that the ethyl acetate (EtOAc) fraction of Andrographis paniculata (AP) possessed anti-inflammatory activity. This study further isolated these active compounds from bioactivity-guided chromatographic fractionation and identified eight pure compounds. |
| In vivo | Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata.[Pubmed: 26214875]Zhong Yao Cai. 2015 Jan;38(1):89-92.To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.
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| Structure Identification | Nat Prod Commun. 2015 Mar;10(3):387-8.Convergent synthesis of moslosooflavone, isowogonin and norwogonin from chrysin.[Pubmed: 25924511]A convergent synthesis route of Moslosooflavone, isowogonin and norwogoninis reported,starting from chrysin, an easily available flavone, by methylation, bromination, methoxylation and demethylation procedures. This synthetic route is convenient and can give the three rare flavones in good yield. |
Moslosooflavone Dilution Calculator
Moslosooflavone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3523 mL | 16.7616 mL | 33.5233 mL | 67.0466 mL | 83.8082 mL |
| 5 mM | 0.6705 mL | 3.3523 mL | 6.7047 mL | 13.4093 mL | 16.7616 mL |
| 10 mM | 0.3352 mL | 1.6762 mL | 3.3523 mL | 6.7047 mL | 8.3808 mL |
| 50 mM | 0.067 mL | 0.3352 mL | 0.6705 mL | 1.3409 mL | 1.6762 mL |
| 100 mM | 0.0335 mL | 0.1676 mL | 0.3352 mL | 0.6705 mL | 0.8381 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition.[Pubmed:20085279]
J Agric Food Chem. 2010 Feb 24;58(4):2505-12.
Previous studies showed that the ethyl acetate (EtOAc) fraction of Andrographis paniculata (AP) possessed anti-inflammatory activity. This study further isolated these active compounds from bioactivity-guided chromatographic fractionation and identified eight pure compounds. Reporter gene assay indicated that 5-hydroxy-7,8-dimethoxyflavone (1), 5-hydroxy-7,8-dimethoxyflavanone (2), a mix of beta-sitosterol (3a) and stigmasterol (3b), ergosterol peroxide (4), 14-deoxy-14,15-dehydroandrographolide (5), and a new compound, 19-O-acetyl-14-deoxy-11,12-didehydroandrographolide (6a), significantly inhibited the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages (P < 0.05). The two most abundant compounds, 14-deoxy-11,12-didehydroandrographolide (7) and andrographolide (8), had less inhibitory activity but exerted greater inhibitory activity by hydrogenation, oxidation, or acetylation to become four derived compounds, 9, 10, 11, and 12. All of the compounds significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells. Compounds 5, 11, and 12 exerted the strongest inhibitory effect on NF-kappaB-dependent transactivation in the RAW 264.7 cell, with IC(50) values of 2, 2.2, and 2.4 microg/mL, respectively, providing encouraging results for bioactive compound development.
[Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata].[Pubmed:26214875]
Zhong Yao Cai. 2015 Jan;38(1):89-92.
OBJECTIVE: To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata. METHODS: The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice. RESULTS: Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), beta-sitosterol(7), lupeol(8), Moslosooflavone (9), mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12). CONCLUSION: All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.
Convergent synthesis of moslosooflavone, isowogonin and norwogonin from chrysin.[Pubmed:25924511]
Nat Prod Commun. 2015 Mar;10(3):387-8.
A convergent synthesis route of moslooflavone, isowogonin and norwogoninis reported,starting from chrysin, an easily available flavone, by methylation, bromination, methoxylation and demethylation procedures. This synthetic route is convenient and can give the three rare flavones in good yield.
