Questinol

CAS# 35688-09-6

Questinol

Catalog No. BCN7443----Order now to get a substantial discount!

Product Name & Size Price Stock
Questinol: 5mg $776 In Stock
Questinol: 10mg Please Inquire In Stock
Questinol: 20mg Please Inquire Please Inquire
Questinol: 50mg Please Inquire Please Inquire
Questinol: 100mg Please Inquire Please Inquire
Questinol: 200mg Please Inquire Please Inquire
Questinol: 500mg Please Inquire Please Inquire
Questinol: 1000mg Please Inquire Please Inquire

Quality Control of Questinol

Number of papers citing our products

Chemical structure

Questinol

3D structure

Chemical Properties of Questinol

Cas No. 35688-09-6 SDF Download SDF
PubChem ID 147621 Appearance Powder
Formula C16H12O6 M.Wt 300.26
Type of Compound Anthraquinones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1,6-dihydroxy-3-(hydroxymethyl)-8-methoxyanthracene-9,10-dione
SMILES COC1=C2C(=CC(=C1)O)C(=O)C3=CC(=CC(=C3C2=O)O)CO
Standard InChIKey SNBGJGNOQURXCI-UHFFFAOYSA-N
Standard InChI InChI=1S/C16H12O6/c1-22-12-5-8(18)4-10-14(12)16(21)13-9(15(10)20)2-7(6-17)3-11(13)19/h2-5,17-19H,6H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Questinol

The cultures of the fungus Talaromyces stipitatus KUFA 0207.

Biological Activity of Questinol

Description1. Questinol exhibits significant anti-obesity activity. 2. Questinol shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 and inhibit NO and PGE2 production.
TargetsNO | PGE | TNF-α | COX | IL Receptor

Questinol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Questinol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Questinol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3304 mL 16.6522 mL 33.3045 mL 66.6089 mL 83.2612 mL
5 mM 0.6661 mL 3.3304 mL 6.6609 mL 13.3218 mL 16.6522 mL
10 mM 0.333 mL 1.6652 mL 3.3304 mL 6.6609 mL 8.3261 mL
50 mM 0.0666 mL 0.333 mL 0.6661 mL 1.3322 mL 1.6652 mL
100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.6661 mL 0.8326 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Questinol

Anti-inflammatory activity of questinol isolated from marine-derived fungus Eurotium amstelodami in lipopolysaccharide-stimulated RAW 264.7 macrophages.[Pubmed:24986678]

J Microbiol Biotechnol. 2014 Oct;24(10):1346-53.

In the present study, an anthraquinone derivative, Questinol was successfully isolated from the broth extract of the marine-derived fungus Eurotium amstelodami for the first time. The structure of Questinol was determined based on the analysis of the MS and NMR spectral data as well as comparison of those data with the published data. Moreover, the anti-inflammatory effect of Questinol in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells was investigated. The results showed that Questinol did not exhibit cytotoxicity in LPS-stimulated RAW 264.7 cells up to 200 microM. Questinol could significantly inhibit NO and PGE2 production at indicated concentrations. Questinol was also found to inhibit the production of pro-inflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6. Furthermore, the western blot analysis showed that Questinol suppressed the expression level of iNOS in a dose-dependent manner. However, Questinol could slightly inhibit the expression of COX-2 at the concentration of 200 microM. Therefore, our study suggests that Questinol might be selected as a promising agent for the prevention and therapy of inflammatory disease.

A New Ergosterol Analog, a New Bis-Anthraquinone and Anti-Obesity Activity of Anthraquinones from the Marine Sponge-Associated Fungus Talaromyces stipitatus KUFA 0207.[Pubmed:28509846]

Mar Drugs. 2017 May 16;15(5). pii: md15050139.

A new ergosterol analog, talarosterone (1) and a new bis-anthraquinone derivative (3) were isolated, together with ten known compounds including palmitic acid, ergosta-4,6,8(14),22-tetraen-3-one, ergosterol-5,8-endoperoxide, cyathisterone (2), emodin (4a), Questinol (4b), citreorosein (4c), fallacinol (4d), rheoemodin (4e) and secalonic acid A (5), from the ethyl acetate extract of the culture of the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207. The structures of the new compounds were established based on extensive 1D and 2D spectral analysis, and in the case of talarosterone (1), the absolute configurations of its stereogenic carbons were determined by X-ray crystallographic analysis. The structure and stereochemistry of cyathisterone (2) was also confirmed by X-ray analysis. The anthraquinones 4a-e and secalonic acid A (5) were tested for their anti-obesity activity using the zebrafish Nile red assay. Only citreorosein (4c) and Questinol (4b) exhibited significant anti-obesity activity, while emodin (4a) and secalonic acid A (5) caused toxicity (death) for all exposed zebrafish larvae after 24 h.

Keywords:

Questinol,35688-09-6,Natural Products, buy Questinol , Questinol supplier , purchase Questinol , Questinol cost , Questinol manufacturer , order Questinol , high purity Questinol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: