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Nicotinic acid

CAS# 59-67-6

Nicotinic acid

Catalog No. BCN8328----Order now to get a substantial discount!

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Quality Control of Nicotinic acid

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Chemical structure

Nicotinic acid

3D structure

Chemical Properties of Nicotinic acid

Cas No. 59-67-6 SDF Download SDF
PubChem ID 938 Appearance White crystalline powder
Formula C6H5NO2 M.Wt 123.11
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Nicotinic acid; Vitamin B3
Solubility DMSO : 50 mg/mL (406.14 mM; Need ultrasonic)
H2O : 10 mg/mL (81.23 mM; Need ultrasonic)
Chemical Name pyridine-3-carboxylic acid
SMILES C1=CC(=CN=C1)C(=O)O
Standard InChIKey PVNIIMVLHYAWGP-UHFFFAOYSA-N
Standard InChI InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Nicotinic acid

The mycelium of Cordyceps sinensis.

Nicotinic acid Dilution Calculator

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Nicotinic acid Molarity Calculator

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Preparing Stock Solutions of Nicotinic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 8.1228 mL 40.6141 mL 81.2282 mL 162.4563 mL 203.0704 mL
5 mM 1.6246 mL 8.1228 mL 16.2456 mL 32.4913 mL 40.6141 mL
10 mM 0.8123 mL 4.0614 mL 8.1228 mL 16.2456 mL 20.307 mL
50 mM 0.1625 mL 0.8123 mL 1.6246 mL 3.2491 mL 4.0614 mL
100 mM 0.0812 mL 0.4061 mL 0.8123 mL 1.6246 mL 2.0307 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Nicotinic acid

Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group. Target: Others Niacin (also known as vitamin B3 and nicotinic acid) is an organic compound with the formula C6H5NO2 and, depending on the definition used, one of the 20 to 80 essential human nutrients. Not enough niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness. Chronic Niacin deficiency leads to a disease called pellagra. The lack of niacin may also be observed in pandemic deficiency disease which is caused by a lack of five crucial vitamins: niacin,vitamin C, thiamin, vitamin D and vitamin A, and is usually found in areas of widespread poverty and malnutrition. Niacin has been used for over 50 years to increase levels of HDL in the blood and has been found to decrease the risk of cardiovascular events modestly in a number of controlled human trials. Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to and are precursors of NAD and NADP in vivo.Nicotinic acid, nicotinamide, and tryptophan (via quinoline acid) are co-factors for nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD converts to NADP by phosphorylation in the presence of the enzyme NAD+ kinase. NADP and NAD are coenzyme for many dehydrogenases, participating in many hydrogen transfer processes. NAD is important in catabolism of fat, carbohydrate, protein, and alcohol, as well as cell signaling and DNA repair, and NADP mostly in anabolism reactions such as fatty acid and cholesterol synthesis.High energy requirements (brain) or high turnover rate (gut, skin) organs are usually the most susceptible to their deficiency.

References:
[1]. Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010 Jun;210(2):353-61. [2]. Wan P, et al. Pellagra: a review with emphasis on photosensitivity. Br J Dermatol. 2011 Jun;164(6):1188-200. [3]. Ishii N, et al. Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases. J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):209-15.

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References on Nicotinic acid

Structural studies of crystalline forms of triamterene with carboxylic acid, GRAS and API molecules.[Pubmed:29755747]

IUCrJ. 2018 Apr 6;5(Pt 3):309-324.

Pharmaceutical salt solvates (dimethyl sulfoxide, DMSO) of the drug triamterene with the coformers acetic, succinic, adipic, pimelic, azelaic and Nicotinic acid and ibuprofen are prepared by liquid-assisted grinding and solvent-evaporative crystallization. The modified DeltapKa rule as proposed by Cruz-Cabeza [(2012 black triangle right). CrystEngComm, 14, 6362-6365] is in close agreement with the results of this study. All adducts were characterized by X-ray diffraction and thermal analytical techniques, including single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry and thermal gravimetric analysis. Hydrogen-bonded motifs combined to form a variety of extended tapes and sheets. Analysis of the crystal structures showed that all adducts existed as salt solvates and contained the amino-pyridinium-carboxyl-ate heterodimer, except for the solvate containing triamterene, ibuprofen and DMSO, as a result of the presence of a strong and stable hemitriamterenium duplex. A search of the Cambridge Structural Database (CSD 5.36, Version 1.18) to determine the frequency of occurrence of the putative supramolecular synthons found in this study showed good agreement with previous work.

Description

Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group.

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