Nicotinic acidCAS# 59-67-6 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 59-67-6 | SDF | Download SDF |
PubChem ID | 938 | Appearance | White crystalline powder |
Formula | C6H5NO2 | M.Wt | 123.11 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Synonyms | Nicotinic acid; Vitamin B3 | ||
Solubility | DMSO : 50 mg/mL (406.14 mM; Need ultrasonic) H2O : 10 mg/mL (81.23 mM; Need ultrasonic) | ||
Chemical Name | pyridine-3-carboxylic acid | ||
SMILES | C1=CC(=CN=C1)C(=O)O | ||
Standard InChIKey | PVNIIMVLHYAWGP-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9) | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Nicotinic acid Dilution Calculator
Nicotinic acid Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 8.1228 mL | 40.6141 mL | 81.2282 mL | 162.4563 mL | 203.0704 mL |
5 mM | 1.6246 mL | 8.1228 mL | 16.2456 mL | 32.4913 mL | 40.6141 mL |
10 mM | 0.8123 mL | 4.0614 mL | 8.1228 mL | 16.2456 mL | 20.307 mL |
50 mM | 0.1625 mL | 0.8123 mL | 1.6246 mL | 3.2491 mL | 4.0614 mL |
100 mM | 0.0812 mL | 0.4061 mL | 0.8123 mL | 1.6246 mL | 2.0307 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group. Target: Others Niacin (also known as vitamin B3 and nicotinic acid) is an organic compound with the formula C6H5NO2 and, depending on the definition used, one of the 20 to 80 essential human nutrients. Not enough niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness. Chronic Niacin deficiency leads to a disease called pellagra. The lack of niacin may also be observed in pandemic deficiency disease which is caused by a lack of five crucial vitamins: niacin,vitamin C, thiamin, vitamin D and vitamin A, and is usually found in areas of widespread poverty and malnutrition. Niacin has been used for over 50 years to increase levels of HDL in the blood and has been found to decrease the risk of cardiovascular events modestly in a number of controlled human trials. Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to and are precursors of NAD and NADP in vivo.Nicotinic acid, nicotinamide, and tryptophan (via quinoline acid) are co-factors for nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD converts to NADP by phosphorylation in the presence of the enzyme NAD+ kinase. NADP and NAD are coenzyme for many dehydrogenases, participating in many hydrogen transfer processes. NAD is important in catabolism of fat, carbohydrate, protein, and alcohol, as well as cell signaling and DNA repair, and NADP mostly in anabolism reactions such as fatty acid and cholesterol synthesis.High energy requirements (brain) or high turnover rate (gut, skin) organs are usually the most susceptible to their deficiency.
References:
[1]. Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010 Jun;210(2):353-61.
[2]. Wan P, et al. Pellagra: a review with emphasis on photosensitivity. Br J Dermatol. 2011 Jun;164(6):1188-200.
[3]. Ishii N, et al. Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases. J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):209-15.
- DL-Methionine
Catalog No.:BCC8318
CAS No.:59-51-8
- Oxindole
Catalog No.:BCN4050
CAS No.:59-48-3
- Procaine
Catalog No.:BCC5210
CAS No.:59-46-1
- Thiamine chloride
Catalog No.:BCN8344
CAS No.:59-43-8
- Sulfaquinoxaline
Catalog No.:BCC9158
CAS No.:59-40-5
- Mepyramine maleate
Catalog No.:BCC6740
CAS No.:59-33-6
- Folic acid
Catalog No.:BCN5375
CAS No.:59-30-3
- D-Galactose
Catalog No.:BCN8528
CAS No.:59-23-4
- 5-BrdU
Catalog No.:BCC5293
CAS No.:59-14-3
- Ethopabate
Catalog No.:BCC8964
CAS No.:59-06-3
- Methotrexate
Catalog No.:BCC2301
CAS No.:59-05-2
- DL-alpha-Tocopherol
Catalog No.:BCN2200
CAS No.:59-02-9
- Nitrofurazone
Catalog No.:BCC3825
CAS No.:59-87-0
- Levodopa
Catalog No.:BCN1098
CAS No.:59-92-7
- Tolazoline HCl
Catalog No.:BCC4321
CAS No.:59-97-2
- Betaine hydrochloride
Catalog No.:BCN6304
CAS No.:590-46-5
- Bethanechol chloride
Catalog No.:BCC4566
CAS No.:590-63-6
- alpha-Endorphin
Catalog No.:BCC1010
CAS No.:59004-96-5
- 8-Hydroxyhyperforin 8,1-hemiacetal
Catalog No.:BCN4091
CAS No.:59014-02-7
- Atropine sulfate monohydrate
Catalog No.:BCC3728
CAS No.:5908-99-6
- Dehydrotoxicarol
Catalog No.:BCN3991
CAS No.:59086-93-0
- Albaspidin AP
Catalog No.:BCN2398
CAS No.:59092-91-0
- (+)-Rhododendrol
Catalog No.:BCN7091
CAS No.:59092-94-3
- Alpha-Angelica lactone
Catalog No.:BCN5001
CAS No.:591-12-8
Structural studies of crystalline forms of triamterene with carboxylic acid, GRAS and API molecules.[Pubmed:29755747]
IUCrJ. 2018 Apr 6;5(Pt 3):309-324.
Pharmaceutical salt solvates (dimethyl sulfoxide, DMSO) of the drug triamterene with the coformers acetic, succinic, adipic, pimelic, azelaic and Nicotinic acid and ibuprofen are prepared by liquid-assisted grinding and solvent-evaporative crystallization. The modified DeltapKa rule as proposed by Cruz-Cabeza [(2012 black triangle right). CrystEngComm, 14, 6362-6365] is in close agreement with the results of this study. All adducts were characterized by X-ray diffraction and thermal analytical techniques, including single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry and thermal gravimetric analysis. Hydrogen-bonded motifs combined to form a variety of extended tapes and sheets. Analysis of the crystal structures showed that all adducts existed as salt solvates and contained the amino-pyridinium-carboxyl-ate heterodimer, except for the solvate containing triamterene, ibuprofen and DMSO, as a result of the presence of a strong and stable hemitriamterenium duplex. A search of the Cambridge Structural Database (CSD 5.36, Version 1.18) to determine the frequency of occurrence of the putative supramolecular synthons found in this study showed good agreement with previous work.