Betaine hydrochlorideCAS# 590-46-5 |
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| Cas No. | 590-46-5 | SDF | Download SDF |
| PubChem ID | 11545 | Appearance | White cryst. |
| Formula | C5H12ClNO2 | M.Wt | 153.60 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | Betaine chloride | ||
| Solubility | H2O : ≥ 43 mg/mL (279.93 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | carboxymethyl(trimethyl)azanium;chloride | ||
| SMILES | C[N+](C)(C)CC(=O)O.[Cl-] | ||
| Standard InChIKey | HOPSCVCBEOCPJZ-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns, which has anti-hypoxic, hepatoprotective, sedative, antipyretic and analgesic effects. Betaine hydrochloride can increase the secreting of thyroxine (T3) and insulin and regulate the metabolism of organism by the hormones, thus it prompts fish growth and also improves intestine figuration. |
| Targets | Histone Methyltransferase |
| In vivo | Growth-promoting mechanism by betaine hydrochloride in Colossoma brachypomum.[Reference: WebLink]Journal of Fisheries of China, 2003, 27(6):564-9.This research was conducted to approach growth-promoting mechanism by Betaine hydrochloride in Colossoma brachypomum fingerlings with average initial weight 83.14±15. 36g during October to December, 1997.
[Effect of betaine hydrochloride on broiler chickens when used alone or in combination with vitamin B12].[Pubmed: 1014365 ]Vet Med Nauki. 1976;13(6):66-71.
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| Animal Research | The sedative, antipyretic and analgesic effects of betaine hydrochloride[Reference: WebLink]Betaine hydrochloride shows promise for treatment of nonalcoholic steatohepatitis.[Reference: WebLink]Inpharma Weekly, 2001, 1311(1):10-10.Betaine hydrochloride shows promise for treatment of nonalcoholic steatohepatitisBetaine-hydrochloride, therapeutic useHepatitis, treatment... Acta Pharm. Sin., 1986, 21(1):61-4.When Betaine hydrochloride was given orally 250～1000 mg/kg, the motor activity of mice was reduced 50～81%. The hypnotic effect of pentobarbital was markedly increased after oral administration of Betaine hydrochloride at the dosage of 500 mg/kg or 1000 mg/kg. Analgesic effect of betaine was demonstrated in mice by the hot plate method (55℃) and the acetic acid writhing test when given intraperitoneally at the dosage of 540 mg/kg or 900 mg/kg. The analgesic effect of betaine (500 mg/kg) was antagonized by prior administration of atropine (5 mg/kg). Betaine hydrochloride (500 mg/kg) given by gastric intubation was shown to have antipyretic effect in rabbits with ⅳ TAB vaccine fever, but not in normotheric rabbits. |
Betaine hydrochloride Dilution Calculator
Betaine hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.5104 mL | 32.5521 mL | 65.1042 mL | 130.2083 mL | 162.7604 mL |
| 5 mM | 1.3021 mL | 6.5104 mL | 13.0208 mL | 26.0417 mL | 32.5521 mL |
| 10 mM | 0.651 mL | 3.2552 mL | 6.5104 mL | 13.0208 mL | 16.276 mL |
| 50 mM | 0.1302 mL | 0.651 mL | 1.3021 mL | 2.6042 mL | 3.2552 mL |
| 100 mM | 0.0651 mL | 0.3255 mL | 0.651 mL | 1.3021 mL | 1.6276 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.
In Vitro:It is found that proliferation of HeLa cells is inhibited significantly upon exposure to increasing Betaine hydrochloride levels with the MTT test (p<0.05). The percentage of S phase cells in the low dose groups (<5 mg/mL) are distinctly higher than in high dose groups, and the rates of Sub-G1 phase are the opposite (p<0.05). A high concentration of Betaine hydrochloride (>5.0 mg/mL) significantly promotes the apoptosis of HeLa cells (p<0.01). SOD activities of the low dose groups are slightly higher than the control group (p<0.05), and there are obvious synchronicity and correlation among the expression of promoting apoptosis genes Bax, P53, Caspase 3 and apoptosis suppression gene Bcl-2. In response to an apoptosis-inducing stimulus, p53 and cyclin D1 can be activated with blockage of the cell cycle at G1/S or S/G2 checkpoints[1].
In Vivo:Liver-to-body weight ratio is attenuated by Betaine hydrochloride supplementation. When Betaine hydrochloride is added to the alcohol-containing liquid diet, both hepatic triglyceride (TG) accumulation and liver injury are significantly reduced. Betaine hydrochloride supplementation attenuates epididymal fat pad mass loss induced by chronic alcohol feeding. Betaine hydrochloride supplementation prevents the depletion of S-adenosylhomocysteine (SAM) and reduces the increase in S-adenosylhomocysteine (SAH), thereby improving the methylation state of the adipose tissue[2].
References:
[1]. Guo Y, et al. Betaine Effects on Morphology, Proliferation, and p53-induced Apoptosis of HeLa Cervical Carcinoma Cells in Vitro. Asian Pac J Cancer Prev. 2015;16(8):3195-201.
[2]. Dou X, et al. Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease. Br J Pharmacol. 2014 Sep;171(17):4073-86.
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[Effect of betaine hydrochloride on broiler chickens when used alone or in combination with vitamin B12].[Pubmed:1014365]
Vet Med Nauki. 1976;13(6):66-71.
The studies were carried out with 2287 broilers aged from 3 to 56 days, divided when one-day-old into four equal groups. The first group were fed the common ration and served as controls. The remaining three groups were experimental, the broilers of the second group being offered the basic common ration enriched with 0.2 per cent betaine. The third group were also given the ordinary ration, however, they received in the drinking water some 10 mug vitamin BUI per one kilogram feed each. The fourth group received both betaine and vitamin B12 at the rates indicated. Results showed that Betaine hydrochloride offered either alone or in combination with vitamin B12 contributes to increasing the liveweight gain of broilers in the course of the starter period, but its use in doses of 0.2 per cent in the finishing period is not effective.
