NirtetralinCAS# 78185-63-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 78185-63-4 | SDF | Download SDF |
| PubChem ID | 182644 | Appearance | Cryst. |
| Formula | C24H30O7 | M.Wt | 430.5 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (5R,6S,7S)-5-(3,4-dimethoxyphenyl)-4-methoxy-6,7-bis(methoxymethyl)-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxole | ||
| SMILES | COCC1CC2=CC3=C(C(=C2C(C1COC)C4=CC(=C(C=C4)OC)OC)OC)OCO3 | ||
| Standard InChIKey | LHQDZANQXMRHIV-LZJOCLMNSA-N | ||
| Standard InChI | InChI=1S/C24H30O7/c1-25-11-16-8-15-10-20-23(31-13-30-20)24(29-5)22(15)21(17(16)12-26-2)14-6-7-18(27-3)19(9-14)28-4/h6-7,9-10,16-17,21H,8,11-13H2,1-5H3/t16-,17-,21+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Nirtetralin suppresses effectively both HBsAg and HBeAg expression. |
| Targets | HBV |
Nirtetralin Dilution Calculator
Nirtetralin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3229 mL | 11.6144 mL | 23.2288 mL | 46.4576 mL | 58.072 mL |
| 5 mM | 0.4646 mL | 2.3229 mL | 4.6458 mL | 9.2915 mL | 11.6144 mL |
| 10 mM | 0.2323 mL | 1.1614 mL | 2.3229 mL | 4.6458 mL | 5.8072 mL |
| 50 mM | 0.0465 mL | 0.2323 mL | 0.4646 mL | 0.9292 mL | 1.1614 mL |
| 100 mM | 0.0232 mL | 0.1161 mL | 0.2323 mL | 0.4646 mL | 0.5807 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Lignans with anti-hepatitis B virus activities from Phyllanthus niruri L.[Pubmed:22131154]
Phytother Res. 2012 Jul;26(7):964-8.
One new lignan, Nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis. These lignans were assayed for anti-hepatitis B virus activities in vitro. Nirtetralin and Nirtetralin A, B effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC(5)(0) values for HBsAg of 9.5 microM (Nirtetralin A), 16.7 microM (Nirtetralin B) and 97.2 microM (Nirtetralin), IC(5)(0) values for HBeAg of 17.4 microM (Nirtetralin A), 69.3 microM (Nirtetralin B) and 232.0 microM (Nirtetralin), respectively.
Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro.[Pubmed:12748977]
Phytother Res. 2003 May;17(5):449-53.
Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multi florus Willd., P. tenellus Roxb. and P. virgatus Forst. f. It was found that niranthin (1), Nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 micro m, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).
