OleosideCAS# 178600-68-5 |
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| Cas No. | 178600-68-5 | SDF | Download SDF |
| PubChem ID | 101042548 | Appearance | Powder |
| Formula | C16H22O11 | M.Wt | 390.3 |
| Type of Compound | Iridoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (4S,5E,6S)-4-(carboxymethyl)-5-ethylidene-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylic acid | ||
| SMILES | CC=C1C(C(=COC1OC2C(C(C(C(O2)CO)O)O)O)C(=O)O)CC(=O)O | ||
| Standard InChIKey | PNMNSRMFRJNZFD-IPEIANHJSA-N | ||
| Standard InChI | InChI=1S/C16H22O11/c1-2-6-7(3-10(18)19)8(14(23)24)5-25-15(6)27-16-13(22)12(21)11(20)9(4-17)26-16/h2,5,7,9,11-13,15-17,20-22H,3-4H2,1H3,(H,18,19)(H,23,24)/b6-2+/t7-,9+,11+,12-,13+,15-,16-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Lepidium sativum
| Description | 1. Oleacein is a strong Angiotensin Converting Enzyme (ACE)-inhibitor (IC50 = 26 uM). |
Oleoside Dilution Calculator
Oleoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5621 mL | 12.8107 mL | 25.6213 mL | 51.2426 mL | 64.0533 mL |
| 5 mM | 0.5124 mL | 2.5621 mL | 5.1243 mL | 10.2485 mL | 12.8107 mL |
| 10 mM | 0.2562 mL | 1.2811 mL | 2.5621 mL | 5.1243 mL | 6.4053 mL |
| 50 mM | 0.0512 mL | 0.2562 mL | 0.5124 mL | 1.0249 mL | 1.2811 mL |
| 100 mM | 0.0256 mL | 0.1281 mL | 0.2562 mL | 0.5124 mL | 0.6405 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation of an angiotensin converting enzyme (ACE) inhibitor from Olea europaea and Olea lancea.[Pubmed:23194770]
Phytomedicine. 1996 Mar;2(4):319-25.
The aqueous extract of the leaves of Olea europaea and Olea lancea both inhibited Angiotensin Converting Enzyme (ACE) in vitro. A bioassay-directed fractionation resulted in the isolation of a strong ACE-inhibitor namely the secoiridoid 2-(3,4-dihydroxyphenyl)ethyl 4-formyl-3-(2-oxoethyl)-4 E-hexenoate (oleacein) (IC(50) = 26 muM). Five secoiridoid glycosides (oleuropein, ligstroside, excelcioside, Oleoside 11-methyl ester, Oleoside) isolated from Oleaceous plants showed no significant ACE-inhibition whereas, after enzymatic hydrolysis, the ACE-inhibition at 0.33 mg/ml was between 64% to 95%. Secoiridoids have not been described previously in the literature as inhibitors of ACE. Oleacein showed a low toxicity in the brine shrimp (Artemia satina) lethality test (LC(50) (24 h) = 969 ppm).
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