Polyporusterone ACAS# 141360-88-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 141360-88-5 | SDF | Download SDF |
| PubChem ID | 10814524.0 | Appearance | Powder |
| Formula | C28H46O6 | M.Wt | 478.66 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S,3R,5R,9R,10R,13R,14S,17S)-17-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one | ||
| SMILES | CC(C)C(C)CC(C(C)(C1CCC2(C1(CCC3C2=CC(=O)C4C3(CC(C(C4)O)O)C)C)O)O)O | ||
| Standard InChIKey | KQBCIGPPRFLKLS-UMQUCXETSA-N | ||
| Standard InChI | InChI=1S/C28H46O6/c1-15(2)16(3)11-24(32)27(6,33)23-8-10-28(34)18-12-20(29)19-13-21(30)22(31)14-25(19,4)17(18)7-9-26(23,28)5/h12,15-17,19,21-24,30-34H,7-11,13-14H2,1-6H3/t16-,17-,19-,21+,22-,23-,24+,25+,26+,27+,28+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Polyporusterone A Dilution Calculator
Polyporusterone A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0892 mL | 10.4458 mL | 20.8917 mL | 41.7833 mL | 52.2291 mL |
| 5 mM | 0.4178 mL | 2.0892 mL | 4.1783 mL | 8.3567 mL | 10.4458 mL |
| 10 mM | 0.2089 mL | 1.0446 mL | 2.0892 mL | 4.1783 mL | 5.2229 mL |
| 50 mM | 0.0418 mL | 0.2089 mL | 0.4178 mL | 0.8357 mL | 1.0446 mL |
| 100 mM | 0.0209 mL | 0.1045 mL | 0.2089 mL | 0.4178 mL | 0.5223 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Dendronobilin B
Catalog No.:BCX0675
CAS No.:1002717-96-5
- 5,7-Dihydroxycoumarin
Catalog No.:BCX0674
CAS No.:2732-18-5
- Urolithin A
Catalog No.:BCX0673
CAS No.:1143-70-0
- Sorbitol
Catalog No.:BCX0672
CAS No.:50-70-4
- Ergolide
Catalog No.:BCX0671
CAS No.:54999-07-4
- Ankaflavin
Catalog No.:BCX0670
CAS No.:50980-32-0
- Bigelovin
Catalog No.:BCX0669
CAS No.:3668-14-2
- Trans-Emodin bianthrone
Catalog No.:BCX0668
CAS No.:61281-20-7
- Apigenin-7-diglucuronide
Catalog No.:BCX0667
CAS No.:74696-01-8
- Safranal
Catalog No.:BCX0666
CAS No.:116-26-7
- N-benzylpentadecanamide
Catalog No.:BCX0665
CAS No.:1572037-13-8
- Isotoosendanin
Catalog No.:BCX0664
CAS No.:97871-44-8
- Cis-Emodin bianthrone
Catalog No.:BCX0677
CAS No.:61281-19-4
- Anhydrosafflor yellow B
Catalog No.:BCX0678
CAS No.:184840-84-4
- Emodin anthrone
Catalog No.:BCX0679
CAS No.:491-60-1
- Polyporusterone B
Catalog No.:BCX0680
CAS No.:141360-89-6
- 1-Methyl Emodin
Catalog No.:BCX0681
CAS No.:3775-08-4
- Maceneolignan H
Catalog No.:BCX0682
CAS No.:1314042-85-7
- 2-hydroxyl emodin-1-methyl ether
Catalog No.:BCX0683
CAS No.:346434-45-5
- Quinquenoside R1
Catalog No.:BCX0684
CAS No.:85013-02-1
- Sequoyitol
Catalog No.:BCX0685
CAS No.:523-92-2
- Cassiaside C2
Catalog No.:BCX0686
CAS No.:1958039-40-1
- 3-Hydroxy-1,2-dimethoxy-anthraquinone
Catalog No.:BCX0687
CAS No.:10383-62-7
- Gentianose
Catalog No.:BCX0688
CAS No.:25954-44-3
Rapid screening, isolation, and activity evaluation of potential xanthine oxidase inhibitors in Polyporus umbellatus and mechanism of action in the treatment of gout.[Pubmed:37798938]
Phytochem Anal. 2024 Jan;35(1):116-134.
INTRODUCTION: Studies show that Polyporus umbellatus has some pharmacological effects in enhancing immunity and against gout. OBJECTIVES: We aimed to establish new techniques for extraction, biological activity screening, and preparation of xanthine oxidase inhibitors (XODIs) from P. umbellatus. METHODS: First, the extraction of P. umbellatus was investigated using the back propagation (BP) neural network genetic algorithm mathematical regression model, and the extraction variables were optimised to maximise P. umbellatus yield. Second, XODIs were rapidly screened using ultrafiltration, and the change of XOD activity was tested by enzymatic reaction kinetics experiment to reflect the inhibitory effect of active compounds on XOD. Meanwhile, the potential anti-gout effects of the obtained active substances were verified using molecular docking, molecular dynamics simulations, and network pharmacology analysis. Finally, with activity screening as guide, a high-speed countercurrent chromatography (HSCCC) method combined with consecutive injection and two-phase solvent system preparation using the UNIFAC mathematical model was successfully developed for separation and purification of XODIs, and the XODIs were identified using MS and NMR. RESULTS: The results verified that Polyporusterone A, polyporusterone B, ergosta-4,6,8(14),22-tetraen-3-one, and ergosta-7,22-dien-3-one of P. umbellatus exhibited high biological affinity towards XOD. Their structures have been further identified by NMR, indicating that the method is effective and applicable for rapid screening and identification of XODIs. CONCLUSION: This study provides new ideas for the search for natural XODIs active ingredients, and the study provide valuable support for the further development of functional foods with potential therapeutic benefits.
Armillaria mellea Symbiosis Drives Metabolomic and Transcriptomic Changes in Polyporus umbellatus Sclerotia.[Pubmed:35185819]
Front Microbiol. 2022 Feb 3;12:792530.
Sclerotia, the medicinal part of Polyporus umbellatus, play important roles in diuresis and renal protection, with steroids and polysaccharides as the main active ingredients. The sclerotia grow and develop only after symbiosis with Armillaria sp. In this study, a systematic metabolomics based on non-targeted UPLC-MS method was carried out between the infected part of the separated cavity wall of the sclerotia (QR) and the uninfected part (the control group, CK) to find and identify differential metabolites. The biosynthetic pathway of characteristic steroids in sclerotia of P. umbellatus was deduced and the content of ergosterol, Polyporusterone A and B in the QR and CK groups were detected with the High Performance Liquid Chromatography (HPLC). Furthermore, the expression patterns of putative genes associated with steroid biosynthesis pathway were also performed with quantitative real-time PCR. The results showed that a total of 258 metabolites originated from fungi with the fragmentation score more than 45 and high resolution mass were identified, based on UPLC-MS metabolomic analysis, and there were 118 differentially expressed metabolites (DEMs) between both groups. The metabolic pathways indicated that steroids, fatty acid and carbohydrate were active and enriched during P. umbellatus sclerotia infected by A. mellea. The content of ergosterol, Polyporusterone A and B in the QR group increased by 32.2, 75.0, and 20.0%, in comparison to that of the control group. The qRT-PCR analysis showed that series of enzymes including C-8 sterol isomerase (ERG2), sterol C-24 methyltransferase (ERG6) and sterol 22-desaturase (ERG5), which played important roles in the final steps of ergosterol biosynthesis, all presented up-regulated patterns in the QR group in P. umbellatus. The comprehensive metabolomic and transcriptomic information will contribute to further study concerning the mechanisms of P. umbellatus sclerotial formation infected by A. mellea in the future.
Inhibitory effects of triterpenes isolated from Chuling (Polyporus umbellatus Fries) on free radical-induced lysis of red blood cells.[Pubmed:15863885]
Biol Pharm Bull. 2005 May;28(5):817-21.
Chuling, sclerotia of Polyporus umbellatus FRIES, has long been used for urological disorders in traditional medicine. In this study, we demonstrated that Chuling in vitro protects red blood cells from 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH)-induced hemolysis. The inhibitory effect was dose-dependent at concentrations of 50 to 1000 microg/ml. Moreover, tests were carried out to identify the main ingredient of Chuling with scavenging effect on free radicals. Triterpene carboxylic acids isolated from the methanol extract of Chuling, namely, Polyporusterone A and polyporusterone B, were found to have inhibitory activities against AAPH-induced lysis of red blood cells. The anti-hemolytic effect was significantly stronger in polyporusterone B compared with Polyporusterone A. Furthermore, the ingestion of 150 mg of Chuling was associated with a significant increase in free-radical scavenging effect of plasma in rats.
Studies of the active substances in herbs used for hair treatment. II. Isolation of hair regrowth substances, acetosyringone and polyporusterone A and B, from Polyporus umbellatus Fries.[Pubmed:10598026]
Biol Pharm Bull. 1999 Nov;22(11):1189-92.
Fractionation of the 50% ethanol extract of Polyporus umbellatus Fries by column chromatography on Amberlite XAD-2, silica gel, Sephadex LH-20 and octadecyl silica gel (ODS) (C18)) monitored by a hair-regrowth activity assay, afforded three active principles, 1, 2 and 3. The structures of 1, 2 and 3 were determined as acetosyringone, Polyporusterone A, and polyporusterone B by comparison of their spectral data with that of authentic samples, respectively. The effects of several compounds related to acetosyringone, 3,4-dihydroxybenzaldehyde or Polyporusterone A on hair regrowth were also investigated.
Studies on constituents of fruit body of Polyporus umbellatus and their cytotoxic activity.[Pubmed:1576664]
Chem Pharm Bull (Tokyo). 1992 Jan;40(1):143-7.
From the crude drug Chorei, the fruit body of Polyporus umbellatus, seven new components named Polyporusterone A, B, C, D, E, F and G, were isolated and their structures were determined on the basis of the spectral data. These compounds showed cytotoxic action on leukemia 1210 cell proliferation.
