Procyanidin B2 3''-O-gallateCAS# 73086-04-1 |
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Number of papers citing our products
| Cas No. | 73086-04-1 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Brown powder |
| Formula | C37H30O16 | M.Wt | 730.6 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Synonyms | Epicatechin-(4β→8)-epicatechin 3''-O-gallate | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Procyanidin B2 3''-O-gallate Dilution Calculator
Procyanidin B2 3''-O-gallate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.3687 mL | 6.8437 mL | 13.6874 mL | 27.3748 mL | 34.2185 mL |
| 5 mM | 0.2737 mL | 1.3687 mL | 2.7375 mL | 5.475 mL | 6.8437 mL |
| 10 mM | 0.1369 mL | 0.6844 mL | 1.3687 mL | 2.7375 mL | 3.4218 mL |
| 50 mM | 0.0274 mL | 0.1369 mL | 0.2737 mL | 0.5475 mL | 0.6844 mL |
| 100 mM | 0.0137 mL | 0.0684 mL | 0.1369 mL | 0.2737 mL | 0.3422 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Procyanidin B2 3''-O-gallate Isolated from Reynoutria elliptica Prevents Glutamate-Induced HT22 Cell Death by Blocking the Accumulation of Intracellular Reactive Oxygen Species.[Pubmed:31454978]
Biomolecules. 2019 Aug 26;9(9). pii: biom9090412.
In this study, we examined the neuroprotective effects of MeOH extract and bioactive compounds obtained from Reynoutria elliptica seeds using HT22 cells from the murine hippocampal cell line as its underlying molecular basis, which has not yet been elucidated. Our study showed that the MeOH extract of R. elliptica seeds strongly protected HT22 cells from glutamate toxicity. To clarify the responsible compound for the neuroprotective effects, we took an interest in procyanidins of R. elliptica since procyanidins are known to exhibit high structural diversity and neuroprotective activity. To isolate the procyanidins efficiently, a phytochemical investigation of the MeOH extract from R. elliptica seeds using the LC/MS-guided isolation approach was applied, and procyanidin B2 3''-O-gallate (1) was successfully isolated. The structure of 1 was elucidated by analyzing the nuclear magnetic resonance spectroscopic data and LC/MS analysis. The neuroprotective activities of 1 were thoroughly examined using HT22 cells. Compound 1 exhibited a strong antioxidant efficacy and blocked glutamate-mediated increase in the reactive oxygen species (ROS) accumulation. Furthermore, compound 1 significantly inhibited the phosphorylation of extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase, which were increased by glutamate. These findings prove that the extract of R. elliptica seeds containing procyanidin B2 3''-O-gallate, which is a strong neuroprotective component, can be used as a functional food forattenuating and regulating neurological disorders.
