Chrysocauloflavone ICAS# 899789-51-6 |
Quality Control & MSDS
Package In Stock
Number of papers citing our products
| Cas No. | 899789-51-6 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Yellow powder |
| Formula | C30H20O10 | M.Wt | 540.5 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Chrysocauloflavone I Dilution Calculator
Chrysocauloflavone I Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.8501 mL | 9.2507 mL | 18.5014 mL | 37.0028 mL | 46.2535 mL |
| 5 mM | 0.37 mL | 1.8501 mL | 3.7003 mL | 7.4006 mL | 9.2507 mL |
| 10 mM | 0.185 mL | 0.9251 mL | 1.8501 mL | 3.7003 mL | 4.6253 mL |
| 50 mM | 0.037 mL | 0.185 mL | 0.37 mL | 0.7401 mL | 0.9251 mL |
| 100 mM | 0.0185 mL | 0.0925 mL | 0.185 mL | 0.37 mL | 0.4625 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Pharmacokinetics, Tissue Distribution and Protein Binding Studies of Chrysocauloflavone I in Rats.[Pubmed:26576031]
Planta Med. 2016 Feb;82(3):217-23.
Chrysocauloflavone I, an unfrequent biflavonoid, was purified from Selaginella doederleinii in this study. It showed cytotoxic effects on three human cancer cells, NCI-H1975, A549, and HepG-2, in vitro. In silico assessment of the physicochemical properties was performed for predicting the permeability and intestinal absorption of the tested compound. Subsequently, a rapid, sensitive, and specific high-performance liquid chromatography method was developed for determination of the compound in different biological samples to ascertain the pharmacokinetics, tissue distribution, and protein binding profiles of this active ingredient in rats. After intravenous dosing of Chrysocauloflavone I at different levels (10 and 20 mg/kg), the elimination half-life was approximately 85 min, and the AUC0-infinity increased with the dose from 148.52 mg/L x min for 10 mg/kg to 399.01 mg/L x min for 20 mg/kg. After single intravenous dosing (20 mg/kg), Chrysocauloflavone I was detected in all tissues studied with higher levels in the heart, blood, and lungs. The results of equilibrium dialysis indicated a very high protein binding degree (over 97%) for Chrysocauloflavone I. After intragastric administration of 100 mg/kg Chrysocauloflavone I to rats, no parent drug was detected in the rat plasma. This is the first report of the favorable bioactivities, plasma pharmacokinetics, tissue distribution, and protein binding profiles of the rare biflavone Chrysocauloflavone I.
