KayaflavoneCAS# 481-45-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 481-45-8 | SDF | Download SDF |
| PubChem ID | 9894522 | Appearance | Yellow powder |
| Formula | C33H24O10 | M.Wt | 580.5 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one | ||
| SMILES | COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)OC)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)OC | ||
| Standard InChIKey | RROKRDUARFDCDH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C33H24O10/c1-39-19-7-4-16(5-8-19)26-14-23(37)32-24(38)15-28(41-3)30(33(32)43-26)20-10-17(6-9-25(20)40-2)27-13-22(36)31-21(35)11-18(34)12-29(31)42-27/h4-15,34-35,38H,1-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Kayaflavone Dilution Calculator
Kayaflavone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7227 mL | 8.6133 mL | 17.2265 mL | 34.4531 mL | 43.0663 mL |
| 5 mM | 0.3445 mL | 1.7227 mL | 3.4453 mL | 6.8906 mL | 8.6133 mL |
| 10 mM | 0.1723 mL | 0.8613 mL | 1.7227 mL | 3.4453 mL | 4.3066 mL |
| 50 mM | 0.0345 mL | 0.1723 mL | 0.3445 mL | 0.6891 mL | 0.8613 mL |
| 100 mM | 0.0172 mL | 0.0861 mL | 0.1723 mL | 0.3445 mL | 0.4307 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibitory activities of biflavonoids against amyloid-beta peptide 42 cytotoxicity in PC-12 cells.[Pubmed:26004578]
Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3.
A major hallmark of Alzheimer's disease is the cerebral accumulation and resulting cytotoxicity of amyloid-beta peptides, particularly Abeta42. In this study, we used an MTT assay to investigate the inhibitory activity of biflavonoids 1-22 against Abeta42 cytotoxicity in PC-12 cell cultures. Cytoprotective effects were observed for the following amentoflavone type biflavonoids: podocarpusflavone B 8, isoginkgetin 10, sciadopitysin 13, and Kayaflavone 15. These biflavonoids exhibited strong activity in tested compounds, with EC50 values of 5.18, 10.77, 9.84, and 5.29 muM, respectively. Cell viability tests of PC-12 cells revealed that biflavonoids 13 and 15 had stronger inhibitory activities than apigenin 23 and (-)-epigallocatechin gallate 24.
[Chemical constituents from Pleione bulbocodioides].[Pubmed:23627123]
Zhong Yao Cai. 2012 Oct;35(10):1602-4.
OBJECTIVE: To study the chemical constituents of Pleione bulbocodioides. METHODS: The compounds were isolated by repeated column chromatography with silica gel, Sephadex LH-20 and ODS-HPLC. The structures were elucidated by analysis of spectroscopic data (1H-NMR, 13C-NMR). RESULTS: Nine compounds were isolated from the EtOAc extract in the rhizoma of Pleione bulbocodioides. Their structures were identified as amentoflavone(I), Kayaflavone(II), gymconopin D(III), methyl(4-OH) phenylacetate (IV), p-hydroxy benzaldehyde(V), p-hydroxybenzcic acid (VI), 4-oxopentanoic acid (VII), p-dihydroxy benzene (VIII), gastrodine (IX). CONCLUSION: Compounds I - IX are isolated from this plant for the first time.
[Flavone and steroid chemical constituents from rhizome of Paris axialis].[Pubmed:21355268]
Zhongguo Zhong Yao Za Zhi. 2010 Nov;35(22):2994-8.
OBJECTIVE: To study the chemical constituents from the rhizome of Paris axialis. METHOD: The compounds were isolated by column chromatography with silica gel and purified by Sephadex LH-20 column chromatography and preparative RP-HPLC. The structures were identified by means of spectroscopic methods. RESULT: Fourteen compounds were isolated from the EtOAc extract and the n-BuOH extract of P. axialis. Their structures were identified as daucosterol (1), stigmasterol-3-O-beta-D-glycopyranoside (2), beta-ecdysterone (3), pennogenin-3-O-alpha-L-arabinofuranosyl (1 --> 4) -[alpha-L -rhamnopyranosyl (1 --> 2)] -beta-D-glycopyranoside (4), diosgenin-3-O-alpha-L- rhamnopy-ranosyl (1 --> 4) -alpha-L-rhamnopyranosyl (1 --> 4) [alpha-L-rhamnopyranosyl (1 --> 2)] -beta-D-glycopyranoside (5), kaempferol (6), rutin (7), myrincitrin (8), 4, 2', 4'-trihydroxychalcone (9), isorhamnetin-3-O-beta-D- glycopyranoside (10), isorhamnetin-3-O-alpha-L-rhamnopyranosyl (1 --> 2) -beta-D-glycopyranoside (11), isorhamnetin-3-O-beta-D-glucpyranosyl (1 --> 6) -beta-D-glycopyranoside (12), Kayaflavone (13), amentoflavone (14). CONCLUSION: Compounds 1-3 and 6-14 are isolated from P. axialis for the first time; and compounds 7-10, 13, 14 are isolated from the genus Paris for the first time.
Selective cytotoxicity of ginkgetin from Selaginella moellendorffii.[Pubmed:9134745]
J Nat Prod. 1997 Apr;60(4):382-4.
Bioassay-directed fractionation of an ethanolic extract of Selaginella moellendorffii has led to the isolation of a known biflavone, ginkgetin (1). A dose-dependent inhibition was observed with 1 on the growth of OVCAR-3 (human ovarian adenocarcinoma) cells with 50% inhibition occurring at 1.8 micrograms/mL. Nonbioactive fractions yielded four additional known biflavones, amentoflavone 7,4',7",4"'-tetramethyl ether, Kayaflavone, podocarpusflavone A, and amentoflavone.
