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Procyanidin B-5 3,3'-di-O-gallate

CAS# 106533-60-2

Procyanidin B-5 3,3'-di-O-gallate

Catalog No. BCN0715----Order now to get a substantial discount!

Product Name & Size Price Stock
Procyanidin B-5 3,3'-di-O-gallate: 5mg $989 In Stock
Procyanidin B-5 3,3'-di-O-gallate: 10mg Please Inquire In Stock
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Procyanidin B-5 3,3'-di-O-gallate: 500mg Please Inquire Please Inquire
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Quality Control of Procyanidin B-5 3,3'-di-O-gallate

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Chemical structure

Procyanidin B-5 3,3'-di-O-gallate

3D structure

Chemical Properties of Procyanidin B-5 3,3'-di-O-gallate

Cas No. 106533-60-2 SDF Download SDF
PubChem ID 3086518 Appearance Brown powder
Formula C44H34O20 M.Wt 882.7
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms Procyanidin B5 3,3'-di-O-gallate
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(2R,3R)-2-(3,4-dihydroxyphenyl)-6-[(2R,3R,4S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyl)oxy-3,4-dihydro-2H-chromen-4-yl]-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
SMILES C1C(C(OC2=C1C(=C(C(=C2)O)C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)OC(=O)C6=CC(=C(C(=C6)O)O)O)O)C7=CC(=C(C=C7)O)O)OC(=O)C8=CC(=C(C(=C8)O)O)O
Standard InChIKey LFBGVECYPPCVDS-QNPRKUGLSA-N
Standard InChI InChI=1S/C44H34O20/c45-19-11-25(50)34-32(12-19)62-41(16-2-4-22(47)24(49)6-16)42(64-44(60)18-9-29(54)39(58)30(55)10-18)36(34)35-26(51)14-31-20(37(35)56)13-33(40(61-31)15-1-3-21(46)23(48)5-15)63-43(59)17-7-27(52)38(57)28(53)8-17/h1-12,14,33,36,40-42,45-58H,13H2/t33-,36-,40-,41-,42-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Procyanidin B-5 3,3'-di-O-gallate Dilution Calculator

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Procyanidin B-5 3,3'-di-O-gallate Molarity Calculator

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Preparing Stock Solutions of Procyanidin B-5 3,3'-di-O-gallate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1329 mL 5.6644 mL 11.3289 mL 22.6578 mL 28.3222 mL
5 mM 0.2266 mL 1.1329 mL 2.2658 mL 4.5316 mL 5.6644 mL
10 mM 0.1133 mL 0.5664 mL 1.1329 mL 2.2658 mL 2.8322 mL
50 mM 0.0227 mL 0.1133 mL 0.2266 mL 0.4532 mL 0.5664 mL
100 mM 0.0113 mL 0.0566 mL 0.1133 mL 0.2266 mL 0.2832 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Procyanidin B-5 3,3'-di-O-gallate

Galloyl esters from rhubarb are potent inhibitors of squalene epoxidase, a key enzyme in cholesterol biosynthesis.[Pubmed:11199136]

Planta Med. 2000 Dec;66(8):753-6.

Galloyl glucoses and galloyl proanthocyanidins obtained from rhubarb (Rhei Rhizoma, Rheum palmatum L., Polygonaceae); e.g. 1,2,6-tri-O-galloyl-beta-D-glucose (IC50 = 0.63 microM), 1,6-di-O-galloyl-2-O-cinnamoyl-beta-D-glucose (IC50 = 0.58 microM), procyanidin B-2 3,3'-di-O-gallate (IC50 = 0.54 microM), and procyanidin B-5 3,3'-di-O-gallate (IC50 = 0.55 microM), were found to be potent inhibitors of rat squalene epoxidase (SE). The inhibition at submicromolar level was far more potent than that of chemically synthesized substrate analogs. It was demonstrated for the first time that the cholesterol-lowering effect of rhubarb may be attributed to the potent inhibition activities of SE, a rate-limiting enzyme of cholesterol biogenesis.

Inhibitory effects of condensed tannins on angiotensin converting enzyme.[Pubmed:3033368]

Jpn J Pharmacol. 1987 Feb;43(2):242-6.

Effects of condensed tannins isolated from Rhei Rhizoma on the activities of angiotensin converting enzyme (ACE) and various proteases were examined in vitro. Among the various condensed tannins tested, procyanidin B-5 3,3'-di-O-gallate and procyanidin C-1 3,3',3"-tri-O-gallate strongly inhibited the activity of ACE. The concentration of procyanidin B-5 3,3'-di-O-gallate required for 50% inhibition of ACE was 1.3 X 10(-6) M. The inhibition of ACE by condensed tannins was reversible and non-competitive, according to dialysis and to Dixon plots. However, over one hundred times the concentration was required to inhibit activities of other proteases such as trypsin, chymotrypsin, leucine aminopeptidase, carboxypeptidase A and urinary kallikrein. These results suggest that the inhibitory effects of condensed tannins on the activities of ACE are specific.

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