Propafenone HCl

CAS# 34183-22-7

Propafenone HCl

Catalog No. BCC5079----Order now to get a substantial discount!

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Propafenone HCl: 5mg $17 In Stock
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Quality Control of Propafenone HCl

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Chemical structure

Propafenone HCl

3D structure

Chemical Properties of Propafenone HCl

Cas No. 34183-22-7 SDF Download SDF
PubChem ID 36708 Appearance Powder
Formula C21H28ClNO3 M.Wt 377.9
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 33.33 mg/mL (88.20 mM; Need ultrasonic)
H2O : 0.67 mg/mL (1.77 mM; Need ultrasonic)
Chemical Name 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
Standard InChIKey XWIHRGFIPXWGEF-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Propafenone HCl

DescriptionPropafenone Hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias. Target: Sodium Channel Propafenone Hydrochloride is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias. According to the Allergic Rhinitis and its Impact on Asthma (ARIA) treatment guidelines, intranasal anti-histamines are recommended for the first line therapy of mild intermittent, moderate/severe intermittent and mild persistent rhinitis (new classification system for rhinitis). Propafenone works by slowing the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitability of the cells. Propafenone is more selective for cells with a high rate, but also blocks normal cells more than class Ia or Ib. Propafenone differs from the prototypical class Ic antiarrhythmic in that it has additional activity as a beta-adrenergic blocker which can cause bradycardia and bronchospasm .

References:
[1]. http://en.wikipedia.org/wiki/Propafenone

Propafenone HCl Dilution Calculator

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Propafenone HCl Molarity Calculator

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Preparing Stock Solutions of Propafenone HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6462 mL 13.231 mL 26.462 mL 52.9241 mL 66.1551 mL
5 mM 0.5292 mL 2.6462 mL 5.2924 mL 10.5848 mL 13.231 mL
10 mM 0.2646 mL 1.3231 mL 2.6462 mL 5.2924 mL 6.6155 mL
50 mM 0.0529 mL 0.2646 mL 0.5292 mL 1.0585 mL 1.3231 mL
100 mM 0.0265 mL 0.1323 mL 0.2646 mL 0.5292 mL 0.6616 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Propafenone HCl

Propafenone Hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

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Description

Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

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