SulfaclozineCAS# 102-65-8 |
Quality Control & MSDS
3D structure
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| Cas No. | 102-65-8 | SDF | Download SDF |
| PubChem ID | 66890 | Appearance | Powder |
| Formula | C10H9ClN4O2S | M.Wt | 284.7 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Sulfachloropyrazine | ||
| Solubility | DMSO : ≥ 29 mg/mL (101.85 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide | ||
| SMILES | C1=CC(=CC=C1N)S(=O)(=O)NC2=CN=CC(=N2)Cl | ||
| Standard InChIKey | QKLPUVXBJHRFQZ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H9ClN4O2S/c11-9-5-13-6-10(14-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Sulfaclozine Dilution Calculator
Sulfaclozine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5125 mL | 17.5623 mL | 35.1247 mL | 70.2494 mL | 87.8117 mL |
| 5 mM | 0.7025 mL | 3.5125 mL | 7.0249 mL | 14.0499 mL | 17.5623 mL |
| 10 mM | 0.3512 mL | 1.7562 mL | 3.5125 mL | 7.0249 mL | 8.7812 mL |
| 50 mM | 0.0702 mL | 0.3512 mL | 0.7025 mL | 1.405 mL | 1.7562 mL |
| 100 mM | 0.0351 mL | 0.1756 mL | 0.3512 mL | 0.7025 mL | 0.8781 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Sulfaclozine is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Target: Antibacterial, Antiparasitic Sulfaclozine is an antibiotic commonly used in poultry for the treatment of coccidiosis and various infectious diseases, in broiler chickens. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
References:
[1]. Sentepe I, et al. Pharmacokinetic of sulfaclozine in broiler chickens. Food Chem Toxicol. 2010 Jan;48(1):448-451.
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Antibiotic residue monitoring results for pork, chicken, and beef samples in Vietnam in 2012-2013.[Pubmed:25601049]
J Agric Food Chem. 2015 Jun 3;63(21):5141-5.
A monitoring plan of residual antibiotics in food of animal origin was conducted in Vietnam from 2012 to 2013. Meat samples were collected from slaughterhouses and retail stores in Ho Chi Minh City and Nha Trang. A total of 28 antibiotics were analyzed using a LC-MS/MS screening method. Sulfonamides, fluoroquinolones, and tilmicosin were detected in some of the samples. Sulfaclozine and fluoroquinolones were mainly detected in chicken samples, and sulfamethazine was mainly detected in pork samples. High levels of sulfonamide residues, ranging between 2500 and 2700 mug/kg Sulfaclozine and between 1300 and 3600 mug/kg sulfamethazine, were present in two chicken and three pork samples, respectively. Tilmicosin was detected at ranges of 150-450 mug/kg in 10 chicken samples. Positive percentages were 17.3, 8.8, and 7.4% for chicken, pork, and beef, respectively, for an average of 11.9%. The results suggest an appropriate withdrawal period after drug administration had not been observed in some livestock.
Drug resistance evaluation of some commonly used anti-coccidial drugs in broiler chickens.[Pubmed:21246941]
J Egypt Soc Parasitol. 2010 Aug;40(2):337-48.
The study investigated some anticoccidial resistance for Amprol, Toltrazuril and Sulfaclozine in experimental infected broiler. Eimeria identification depended on necropsy and coproscopic examination. 140 day-old chicks allotted into 7 groups and infected with Eimeria in 2nd day of age. G1: neither infected nor treated (negative control), G2: infected but not treated (positive control), Infected and treated with toltrazuril (G3), or with Amprol+Allicin (G4), or with Amprol+ethobabate (G5), or with Amprol (G6) or with Sulfaclozine (G7). Eimeria infection caused decrease in body gain, total protein, albumin but increase in FCR, ALT, AST, Uric acid, Creatinine. Treatment decreased the harmful effect of infection but some significant differences were between infected treated groups and non infected non-treated one.
