LX-4211SGLT1/SGLT2 inhibitor CAS# 1018899-04-1 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1018899-04-1 | SDF | Download SDF |
| PubChem ID | 24831714 | Appearance | Powder |
| Formula | C21H25ClO5S | M.Wt | 424.94 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Sotagliflozin; LP-802034 | ||
| Solubility | DMSO : ≥ 100 mg/mL (235.33 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol | ||
| SMILES | CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)SC)O)O)O)Cl | ||
| Standard InChIKey | QKDRXGFQVGOQKS-CRSSMBPESA-N | ||
| Standard InChI | InChI=1S/C21H25ClO5S/c1-3-26-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-18(24)17(23)19(25)21(27-20)28-2/h4-9,11,17-21,23-25H,3,10H2,1-2H3/t17-,18-,19+,20+,21-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | LX-4211 is a potent dual SGLT2/1 inhibitor; Antidiabetic agents.
IC50 value:
Target: SGLT1/2
LX4211 enhanced urinary glucose excretion by inhibiting SGLT2-mediated renal glucose reabsorption; markedly and significantly improved multiple measures of glycemic control, including fasting plasma glucose, oral glucose tolerance, and HbA(1c); and significantly lowered serum triglycerides. LX4211 also mediated trends for lower weight, lower blood pressure, and higher glucagon-like peptide-1 levels. In a follow-up single-dose study in 12 patients with T2DM, LX4211 (300 mg) significantly increased glucagon-like peptide-1 and peptide YY levels relative to pretreatment values, probably by delaying SGLT1-mediated intestinal glucose absorption [1]. LX4211-treated mice and SGLT1-/- mice also had increased GLP-1 AUC values, decreased glucose-dependent insulinotropic polypeptide (GIP) AUC values, and decreased blood glucose excursions during the 6 hours after a challenge with oral glucose alone [2]. References: | |||||
LX-4211 Dilution Calculator
LX-4211 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3533 mL | 11.7664 mL | 23.5327 mL | 47.0655 mL | 58.8318 mL |
| 5 mM | 0.4707 mL | 2.3533 mL | 4.7065 mL | 9.4131 mL | 11.7664 mL |
| 10 mM | 0.2353 mL | 1.1766 mL | 2.3533 mL | 4.7065 mL | 5.8832 mL |
| 50 mM | 0.0471 mL | 0.2353 mL | 0.4707 mL | 0.9413 mL | 1.1766 mL |
| 100 mM | 0.0235 mL | 0.1177 mL | 0.2353 mL | 0.4707 mL | 0.5883 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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LX-4211 is a dual SGLT2/1 inhibitor; Antidiabetic agents.
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American Diabetes Association--70th scientific sessions--research on novel therapeutics: part 1.[Pubmed:20799136]
IDrugs. 2010 Sep;13(9):595-7.
The American Diabetes Association 70th Scientific Sessions, held in Orlando, FL, USA, included topics covering new therapeutic developments in the field of diabetes research. This conference report highlights selected presentations on new research with novel agents. Investigational drugs discussed include the glucagon-like peptide-1 (GLP-1) agonist taspoglutide (Roche Holding AG/Teijin Ltd/ Chugai Pharmaceutical Co Ltd), the GLP-1 analog SKL-18287 (Sanwa Kagaku Kenkyusho Co Ltd), the sodium glucose transporter-2 (SGLT2) inhibitor ASP-1941 (Astellas Pharma Inc/Kotobuki Pharmaceutical Co Ltd), the dual SGLT2/1 inhibitor LX-4211 (Lexicon Pharmaceuticals Inc), and the selective PPARgamma modulator INT-131 (InteKrin Therapeutics Inc).
Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.
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