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7-O-Demethyl-3-isomangostin hydrate

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7-O-Demethyl-3-isomangostin hydrate

Catalog No. BCN7882----Order now to get a substantial discount!

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Quality Control of 7-O-Demethyl-3-isomangostin hydrate

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Chemical structure

7-O-Demethyl-3-isomangostin hydrate

3D structure

Chemical Properties of 7-O-Demethyl-3-isomangostin hydrate

Cas No. N/A SDF Download SDF
PubChem ID 102004512 Appearance Yellow powder
Formula C23H26O7 M.Wt 414.5
Type of Compound Xanthones Storage Desiccate at -20°C
Synonyms 7-O-Demethyl-3-isomagosti hydrate
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,8,9-trihydroxy-7-(3-hydroxy-3-methylbutyl)-2,2-dimethyl-3,4-dihydropyrano[3,2-b]xanthen-6-one
SMILES CC1(CCC2=C(O1)C=C3C(=C2O)C(=O)C4=C(C(=C(C=C4O3)O)O)CCC(C)(C)O)C
Standard InChIKey ODPJZFJTDFGSOM-UHFFFAOYSA-N
Standard InChI InChI=1S/C23H26O7/c1-22(2,28)7-5-12-17-15(9-13(24)19(12)25)29-16-10-14-11(6-8-23(3,4)30-14)20(26)18(16)21(17)27/h9-10,24-26,28H,5-8H2,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7-O-Demethyl-3-isomangostin hydrate

The fruits of Garcinia mangostana

Biological Activity of 7-O-Demethyl-3-isomangostin hydrate

Descriptiontrans-Communic acid exhibits protective effects against UVB-induced skin aging by suppressing UVB-induced MMP-1 expression. trans-Communic acid shows considerable cytotoxicity against four human cancer cell lines in vitro.It also shows good activity against Mycobacterium aurum (MIC of 13.2 microM).
TargetsAP-1 | JNK | Akt | MAPK | PI3K | MMP(e.g.TIMP) | Antifection
In vitro

Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K.[Pubmed: 26066652]

PLoS One. 2015 Jun 11;10(6):e0128365.

Japanese red pine (Pinus densiflora) is widely present in China, Japan, and Korea. Its green pine leaves have traditionally been used as a food as well as a coloring agent. After being shed, pine leaves change their color from green to brown within two years, and although the brown pine leaves are abundantly available, their value has not been closely assessed.
METHODS AND RESULTS:
In this study, we investigated the potential anti-photoaging properties of brown pine leaves for skin. Brown pine leaf extract (BPLE) inhibited UVB-induced matrix metalloproteinase-1 (MMP-1) expression to a greater extent than pine leaf extract (PLE) in human keratinocytes and a human skin equivalent model. HPLC analysis revealed that the quantity of trans-Communic acid (TCA) and dehydroabietic acid (DAA) significantly increases when the pine leaf color changes from green to brown. BPLE and TCA elicited reductions in UVB-induced MMP-1 mRNA expression and activator protein-1 (AP-1) transactivation by reducing DNA binding activity of phospho-c-Jun, c-fos and Fra-1. BPLE and TCA also inhibited UVB-induced Akt phosphorylation, but not mitogen activated protein kinase (MAPK), known regulators of AP-1 transactivation. We additionally found that BPLE and TCA inhibited phosphoinositide 3-kinase (PI3K), the upstream kinase of Akt, in vitro. In summary, both BPLE and its active component TCA exhibit protective effects against UVB-induced skin aging.
CONCLUSIONS:
Taken together, these findings underline the potential for BPLE and TCA to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression.

Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae).[Pubmed: 19755141]

J Ethnopharmacol. 2009 Dec 10;126(3):500-5.

The antimycobacterial activity of Juniperus communis was attributed to a sesquiterpene identified as longifolene (1) and two diterpenes, characterised as totarol (2) and trans-Communic acid (3).
METHODS AND RESULTS:
All compounds were identified following analysis of their spectroscopic data (1D- and 2D-NMR, MS) and by comparison with the literature and commercial authentic standards when available. Revised assignments for 3 are reported. Totarol showed the best activity against Mycobacterium tuberculosis H(37)Rv (MIC of 73.7 microM). It was also most active against the isoniazid-, streptomycin-, and moxifloxacin-resistant variants (MIC of 38.4, 83.4 and 60 microM, respectively). Longifolene and totarol were most active against the rifampicin-resistant variant (MICs of 24 and 20.2 microM, respectively). Totarol showed the best activity in the LORA assay (MIC of 81.3 microM) and against all NTM species (MICs in the range of 7-14 microM). trans-Communic acid showed good activity against Mycobacterium aurum (MIC of 13.2 microM). The low selectivity indices (SI) obtained following cytotoxicity studies indicated that the isolated terpenoids were relatively toxic towards mammalian cells.
CONCLUSIONS:
This is the first report of the isolation of (1) and (2) from Juniperus communis roots, and of (3) from the aerial parts. The antimycobacterial activity of (1) and (3), and the activity of (2) against Mycobacterium aurum, Mycobacterium fortuitum and Mycobacterium phlei, is reported for the first time. The effect of totarol on drug-resistant variants and non-replicating Mycobacterium tuberculosis has never been published.

Protocol of 7-O-Demethyl-3-isomangostin hydrate

Structure Identification
Arch Pharm Res. 2011 Dec;34(12):2043-9.

A new lignan glycoside from Juniperus rigida.[Pubmed: 22210029 ]

A new lignan glycoside, named juniperigiside (1) was isolated from the CHCl(3) soluble fraction of the MeOH extract of stems and leaves of Juniperus rigida S.et Z.
METHODS AND RESULTS:
Compound 1 was identified by 1D- and 2D-NMR spectroscopy as well as CD analysis as (2R,3S)-2,3-dihydro-7-methoxy-2-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-5-benzofuranpropanol 4'-O-(3-O-methyl)-α-L-rhamnopyranoside. Five known lignans, icariside E4 (2), desoxypodophyllotoxin (3), savinin (4), thujastandin (5), and (-)-nortrachelogenin (6) in addition to five known labdane diterpenes including trans-Communic acid (7), 13-epi-torulosal (8), 13-epi-cupressic acid (9), imbricatoric acid (10), and isocupressic acid (11) were also isolated and their structures were characterized by comparing their spectroscopic data with those in the literature. All compounds were isolated for the first time from this plant, and 5 and 6 were first reported from the genus Juniperus. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay.
CONCLUSIONS:
Compounds 3, 4, 7, and 8 showed considerable cytotoxicity against four human cancer cell lines in vitro.

7-O-Demethyl-3-isomangostin hydrate Dilution Calculator

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7-O-Demethyl-3-isomangostin hydrate Molarity Calculator

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Preparing Stock Solutions of 7-O-Demethyl-3-isomangostin hydrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4125 mL 12.0627 mL 24.1255 mL 48.2509 mL 60.3136 mL
5 mM 0.4825 mL 2.4125 mL 4.8251 mL 9.6502 mL 12.0627 mL
10 mM 0.2413 mL 1.2063 mL 2.4125 mL 4.8251 mL 6.0314 mL
50 mM 0.0483 mL 0.2413 mL 0.4825 mL 0.965 mL 1.2063 mL
100 mM 0.0241 mL 0.1206 mL 0.2413 mL 0.4825 mL 0.6031 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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