TC HSD 21

CAS# 330203-01-5

TC HSD 21

Catalog No. BCC6228----Order now to get a substantial discount!

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TC HSD 21: 5mg $92 In Stock
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Chemical structure

TC HSD 21

3D structure

Chemical Properties of TC HSD 21

Cas No. 330203-01-5 SDF Download SDF
PubChem ID 1774851 Appearance Powder
Formula C17H12BrNO3S2 M.Wt 422.32
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO
Chemical Name (5Z)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
SMILES COC1=CC=C(C=C1)N2C(=O)C(=CC3=CC(=C(C=C3)O)Br)SC2=S
Standard InChIKey HEFKAUYVLSGPGC-DHDCSXOGSA-N
Standard InChI InChI=1S/C17H12BrNO3S2/c1-22-12-5-3-11(4-6-12)19-16(21)15(24-17(19)23)9-10-2-7-14(20)13(18)8-10/h2-9,20H,1H3/b15-9-
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of TC HSD 21

DescriptionPotent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 values are 6 and 40 nM at human and mouse 17β-HSD3 respectively). Displays no activity at 17β-HSD1, 17β-HSD2, ERα, androgen receptors or glucocorticoid receptors.

TC HSD 21 Dilution Calculator

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TC HSD 21 Molarity Calculator

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Preparing Stock Solutions of TC HSD 21

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3679 mL 11.8394 mL 23.6787 mL 47.3575 mL 59.1968 mL
5 mM 0.4736 mL 2.3679 mL 4.7357 mL 9.4715 mL 11.8394 mL
10 mM 0.2368 mL 1.1839 mL 2.3679 mL 4.7357 mL 5.9197 mL
50 mM 0.0474 mL 0.2368 mL 0.4736 mL 0.9471 mL 1.1839 mL
100 mM 0.0237 mL 0.1184 mL 0.2368 mL 0.4736 mL 0.592 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on TC HSD 21

Identification of oxazolidinediones and thiazolidinediones as potent 17beta-hydroxysteroid dehydrogenase type 3 inhibitors.[Pubmed:22137341]

Bioorg Med Chem Lett. 2012 Jan 1;22(1):504-7.

Novel and potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) were identified based on oxazolidinedione and thiazolidinedione derivatives, starting from a high-throughput screening hit, 5-(3-bromo-4-hydroxybenzyl)-3-(4-methoxyphenyl)-1,3-thiazol-2-one. 5-(3-Bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-o ne exhibited a promising activity profile and demonstrated significant selectivity over the related 17beta-HSD isoenzymes and nuclear receptors.

Description

TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors.

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