TC HSD 21CAS# 330203-01-5 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 330203-01-5 | SDF | Download SDF |
| PubChem ID | 1774851 | Appearance | Powder |
| Formula | C17H12BrNO3S2 | M.Wt | 422.32 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| Chemical Name | (5Z)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one | ||
| SMILES | COC1=CC=C(C=C1)N2C(=O)C(=CC3=CC(=C(C=C3)O)Br)SC2=S | ||
| Standard InChIKey | HEFKAUYVLSGPGC-DHDCSXOGSA-N | ||
| Standard InChI | InChI=1S/C17H12BrNO3S2/c1-22-12-5-3-11(4-6-12)19-16(21)15(24-17(19)23)9-10-2-7-14(20)13(18)8-10/h2-9,20H,1H3/b15-9- | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 values are 6 and 40 nM at human and mouse 17β-HSD3 respectively). Displays no activity at 17β-HSD1, 17β-HSD2, ERα, androgen receptors or glucocorticoid receptors. |
TC HSD 21 Dilution Calculator
TC HSD 21 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3679 mL | 11.8394 mL | 23.6787 mL | 47.3575 mL | 59.1968 mL |
| 5 mM | 0.4736 mL | 2.3679 mL | 4.7357 mL | 9.4715 mL | 11.8394 mL |
| 10 mM | 0.2368 mL | 1.1839 mL | 2.3679 mL | 4.7357 mL | 5.9197 mL |
| 50 mM | 0.0474 mL | 0.2368 mL | 0.4736 mL | 0.9471 mL | 1.1839 mL |
| 100 mM | 0.0237 mL | 0.1184 mL | 0.2368 mL | 0.4736 mL | 0.592 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Identification of oxazolidinediones and thiazolidinediones as potent 17beta-hydroxysteroid dehydrogenase type 3 inhibitors.[Pubmed:22137341]
Bioorg Med Chem Lett. 2012 Jan 1;22(1):504-7.
Novel and potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) were identified based on oxazolidinedione and thiazolidinedione derivatives, starting from a high-throughput screening hit, 5-(3-bromo-4-hydroxybenzyl)-3-(4-methoxyphenyl)-1,3-thiazol-2-one. 5-(3-Bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-o ne exhibited a promising activity profile and demonstrated significant selectivity over the related 17beta-HSD isoenzymes and nuclear receptors.
TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors.
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