Teuclatriol

CAS# 152110-17-3

Teuclatriol

Catalog No. BCN1676----Order now to get a substantial discount!

Product Name & Size Price Stock
Teuclatriol: 5mg $903 In Stock
Teuclatriol: 10mg Please Inquire In Stock
Teuclatriol: 20mg Please Inquire Please Inquire
Teuclatriol: 50mg Please Inquire Please Inquire
Teuclatriol: 100mg Please Inquire Please Inquire
Teuclatriol: 200mg Please Inquire Please Inquire
Teuclatriol: 500mg Please Inquire Please Inquire
Teuclatriol: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Teuclatriol

Number of papers citing our products

Chemical structure

Teuclatriol

3D structure

Chemical Properties of Teuclatriol

Cas No. 152110-17-3 SDF Download SDF
PubChem ID 91884970 Appearance Oil
Formula C15H28O3 M.Wt 256.4
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,3aR,4R,7S,8R,8aR)-1,4-dimethyl-7-propan-2-yl-2,3,3a,5,6,7,8,8a-octahydroazulene-1,4,8-triol
SMILES CC(C)C1CCC(C2CCC(C2C1O)(C)O)(C)O
Standard InChIKey CXQOZINRAFPQEX-QFEQQRJNSA-N
Standard InChI InChI=1S/C15H28O3/c1-9(2)10-5-7-14(3,17)11-6-8-15(4,18)12(11)13(10)16/h9-13,16-18H,5-8H2,1-4H3/t10-,11+,12+,13+,14+,15-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Teuclatriol

The herb of Teucrium leucocladium.

Biological Activity of Teuclatriol

Description1. Teuclatriol showed a significant anti-proliferative effect on human activated-peripheral blood lymphocytes (IC50, 72.8 ± 5.4 µg/ml). 2. Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312µM and higher.
TargetsNF-kB | TNF-α | TLR

Teuclatriol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Teuclatriol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Teuclatriol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9002 mL 19.5008 mL 39.0016 mL 78.0031 mL 97.5039 mL
5 mM 0.78 mL 3.9002 mL 7.8003 mL 15.6006 mL 19.5008 mL
10 mM 0.39 mL 1.9501 mL 3.9002 mL 7.8003 mL 9.7504 mL
50 mM 0.078 mL 0.39 mL 0.78 mL 1.5601 mL 1.9501 mL
100 mM 0.039 mL 0.195 mL 0.39 mL 0.78 mL 0.975 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Teuclatriol

[Chemical constituents of Acorus calamus].[Pubmed:23373216]

Zhongguo Zhong Yao Za Zhi. 2012 Nov;37(22):3430-3.

OBJECTIVE: To study the chemical constituents contained in Acorus calamus. METHOD: The chemical constituents were separated and purified by various chromatographic methods including silica gel, ODS, HPLC and Sephadex LH-20, and their structures were identified on the basis of analysis on spectroscopic data. RESULT: Ten compounds were separated from A. calamus and identified as 1beta, 4beta, 7alpha-trihydroxyeudesmane (1), bullatantriol (2), Teuclatriol (3), threo-1', 2'-dihydroxyasarone (4), erythro-1', 2'-dihydroxyasarone (5), (+)-de-4'-O-methyleudesmin (6), (+)-de-4'-0-methylmagnolin (7), (+)-eudesmin (8), (+)-magnolin (9) and beta-sitosterol (10), respectively. CONCLUSION: Compounds 1-2,4-9 were separated from this plant for the first time. Specifically, compounds 1-2,6-9 were obtained from Acorus genus for the first time.

Inhibitory effects of teuclatriol, a sesquiterpene from salvia mirzayanii, on nuclear factor-kappaB activation and expression of inflammatory mediators.[Pubmed:25446581]

J Ethnopharmacol. 2015 Feb 3;160:94-100.

ETHNOPHARMACOLOGICAL RELEVANCE: Salvia mirzayanii Rech. f. & Esfand. is an endemic plant, which is only distributed in the south of Iran. In traditional Iranian medicine, the aerial parts of Salvia mirzayanii have been used for infections, inflammatory diseases, and as a tonic. From this plant, the sesquiterpene Teuclatriol was isolated by bioactivity-guided fractionation due to its anti-proliferative actions on human lymphocytes. The guaiane sesquiterpene is lacking the methylene-gamma-lactone function that is typically involved in the inhibiting properties of sesquiterpenes on NF-kappaB, a pivotal transcription factor in inflammatory processes. We here investigated anti-inflammatory effects of Teuclatriol on human macrophage-like and endothelial cells. MATERIALS AND METHODS: Non-toxic doses of Teuclatriol were determined for both cell types by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)-assay. The effect of Teuclatriol on the activity of NF-kappaB in LPS-stimulated human monocytic THP-1 cells was studied using infrared electrophoretic mobility shift assay (IR-EMSA) using curcumin as positive control (32microM). THP-1 were differentiated into macrophage-like cells and evaluated for TNF-alpha secretion by L929 bioassay following stimulation with LPS and treatment with Teuclatriol. Inflammatory gene expression in human umbilical vein endothelial cells (HUVEC), modeling target cells for TNF-alpha-induced inflammatory gene activation, was investigated by real-time RT-PCR. RESULTS: The LPS-induced DNA binding activity of NF-kappaB in THP-1 was significantly decreased by non-toxic doses of Teuclatriol (312 and 390microM). Teuclatriol reduced the production of TNF-alpha in a dose-dependent manner. mRNA levels of both monocyte chemoattractant protein (MCP)-1 and toll-like receptor (TLR)2 were decreased in TNF-alpha-activated HUVEC. CONCLUSION: These data show an inhibitory effect of Teuclatriol on NF-kappaB signaling at doses of 312microM and higher, validating the traditional use of Salvia mirzayanii in the treatment of inflammatory diseases. Future work on the mode of action of Teuclatriol may provide new lead structures with NF-kappaB inhibiting properties, lacking possible side effects mediated via alkylating centers of sesquiterpene lactones.

Immunoinhibitory effect of teuclatriol a guaiane sesquiterpene from Salvia mirzayanii.[Pubmed:22201620]

Iran J Immunol. 2011 Dec;8(4):226-35.

BACKGROUND: Salvia mirzayanii, a native plant to Iran, is shown to have immunomodulatory effects on lymphocyte proliferation. OBJECTIVE: To identify the bioactive immunomodulatory compound(s) present in S. mirzayanii. METHODS: The crude extract was fractionated to five fractions in two steps using different solvents. The fractions were subjected to bioassay-guided fractionation. All the fractions were tested for bioactivity on human activated-peripheral blood lymphocytes (PBLs) using cell proliferation assay. RESULTS: The methanol fraction (Fr. M) showed the highest inhibitory effect on PBLs compared to other fractions. Fr. M was applied on a gravity column chromatography for further fractionation. Resultant fractions, demonstrated inhibitory effects at higher concentrations. Fr. 4 with an 18.9 +/- 0.2% inhibitory activity at 200 microg/ml and with the highest quantity was applied on preparative TLC plates for further purification. The final purified compound was identified as Teuclatriol, a guaiane sesquiterpene, by NMR analysis. This compound showed a significant anti-proliferative effect on human activated-peripheral blood lymphocytes (IC50, 72.8 +/- 5.4 microg/ml). CONCLUSION: Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii. We suggest further studies on Teuclatriol, exploring its mechanism of action as an immunomodulatory compound.

Keywords:

Teuclatriol,152110-17-3,Natural Products, buy Teuclatriol , Teuclatriol supplier , purchase Teuclatriol , Teuclatriol cost , Teuclatriol manufacturer , order Teuclatriol , high purity Teuclatriol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: