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Tolfenpyrad

CAS# 129558-76-5

Tolfenpyrad

2D Structure

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Tolfenpyrad

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Chemical Properties of Tolfenpyrad

Cas No. 129558-76-5 SDF Download SDF
PubChem ID 10110536 Appearance Powder
Formula C21H22ClN3O2 M.Wt 383.87
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : ≥ 56 mg/mL (145.88 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name 4-chloro-5-ethyl-2-methyl-N-[[4-(4-methylphenoxy)phenyl]methyl]pyrazole-3-carboxamide
SMILES CCC1=NN(C(=C1Cl)C(=O)NCC2=CC=C(C=C2)OC3=CC=C(C=C3)C)C
Standard InChIKey WPALTCMYPARVNV-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H22ClN3O2/c1-4-18-19(22)20(25(3)24-18)21(26)23-13-15-7-11-17(12-8-15)27-16-9-5-14(2)6-10-16/h5-12H,4,13H2,1-3H3,(H,23,26)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Tolfenpyrad

DescriptionTolfenpyrad is a pesticide that was first approved in 2002 in Japan under the trade name of Hachi-hachi.

References:
[1]. Yamaguchi K, et al. Analysis of tolfenpyrad and its metabolites in plasma in a tolfenpyrad poisoning case. J Anal Toxicol. 2012 Sep;36(7):529-37. [2]. Hikiji W, et al. Acute fatal poisoning with Tolfenpyrad. J Forensic Leg Med. 2013 Nov;20(8):962-4.

Tolfenpyrad Dilution Calculator

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Preparing Stock Solutions of Tolfenpyrad

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.605 mL 13.0252 mL 26.0505 mL 52.101 mL 65.1262 mL
5 mM 0.521 mL 2.605 mL 5.2101 mL 10.4202 mL 13.0252 mL
10 mM 0.2605 mL 1.3025 mL 2.605 mL 5.2101 mL 6.5126 mL
50 mM 0.0521 mL 0.2605 mL 0.521 mL 1.042 mL 1.3025 mL
100 mM 0.0261 mL 0.1303 mL 0.2605 mL 0.521 mL 0.6513 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Tolfenpyrad

Tolfenpyrad is a pesticide that was first approved in 2002 in Japan under the trade name of Hachi-hachi.

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References on Tolfenpyrad

Analysis of tolfenpyrad and its metabolites in plasma in a tolfenpyrad poisoning case.[Pubmed:22802573]

J Anal Toxicol. 2012 Sep;36(7):529-37.

Tolfenpyrad (TFP) is a pesticide that was first approved in 2002 in Japan under the trade name of Hachi-hachi. Analyses of TFP and its major metabolite, 4-[4-[(4-chloro-3-ethyl-1-methylpyrazol-5-yl)carbonylaminomethyl]phenoxy]benzoic acid (PTCA), in plasma obtained from a cadaver suspected to have died of TFP poisoning, were conducted by liquid chromatography-mass spectrometry. The existence of TFP and PTCA was confirmed by scan mode and quantitative analysis was performed by selected ion monitoring mode. Calibration curves showed good linearity over the range of 0.1-4 and 0.25-4 microg/mL, and concentrations were estimated to be 1.97 +/- 0.02 and 2.88 +/- 0.04 microg/mL for TFP and PTCA, respectively. The plasma extract was further examined to find other metabolites using quadrupole time-of-flight MS, and the results revealed three more metabolites, which were suggested to be hydroxy-TFP, dehydro-TFP and hydroxy-PTCA. Plausible metabolic pathways of TFP in humans are: (i) oxidation of the methyl group on the benzene ring, and (ii) hydroxylation followed by dehydration at the ethyl group on the pyrazole ring.

Acute fatal poisoning with Tolfenpyrad.[Pubmed:24237799]

J Forensic Leg Med. 2013 Nov;20(8):962-4.

The authors present a fatal case of poisoning with Tolfenpyrad (TFP), a pesticide first approved in Japan in 2002. A man in his fifties was found dead in the supine position at his son's home and the small towel with a smell of naphthalene was found nearby. Forensic autopsy was unremarkable, except for a very small amount of light pink fluid in the stomach, with naphthalene odour. The toxicological analyses revealed the presence of TFP and its major metabolite PTCA (4-[4-[(4-chloro-3-ethyl-1-methylpyrazol-5-yl)carbonylaminomethyl]phenoxy]benzoic acid), together with naphthalene and methyl naphthalenes in the post-mortem sample, with liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) respectively. The plasma concentrations of each substance were quantified as 1.97 mug/ml (TFP), 2.88 mug/ml (PTCA), 1.70 mug/ml (naphthalene), 0.67 mug/ml (1-methyl naphthalene) and 1.44 mug/ml (2-methyl naphthalene). According to these results together with autopsy findings, the cause of his death was determined to be acute Tolfenpyrad poisoning. This is the first case report of fatal poisoning attributable to an intake of TFP product.

Description

Tolfenpyrad is a pesticide that was first approved in 2002 in Japan.

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