Torilolone

CAS# 13018-09-2

Torilolone

Catalog No. BCN6659----Order now to get a substantial discount!

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Torilolone: 5mg $914 In Stock
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Quality Control of Torilolone

Number of papers citing our products

Chemical structure

Torilolone

3D structure

Chemical Properties of Torilolone

Cas No. 13018-09-2 SDF Download SDF
PubChem ID 10444938 Appearance Cryst.
Formula C15H24O3 M.Wt 252.4
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (5S,6R,8S,8aR)-6-hydroxy-5-(2-hydroxypropan-2-yl)-3,8-dimethyl-4,5,6,7,8,8a-hexahydro-1H-azulen-2-one
SMILES CC1CC(C(CC2=C(C(=O)CC12)C)C(C)(C)O)O
Standard InChIKey ZLDODTPRRLQGHP-LGYCOIBBSA-N
Standard InChI InChI=1S/C15H24O3/c1-8-5-14(17)12(15(3,4)18)6-11-9(2)13(16)7-10(8)11/h8,10,12,14,17-18H,5-7H2,1-4H3/t8-,10+,12-,14+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Torilolone

The herbs of Cnidium monnieri.

Biological Activity of Torilolone

Description1. Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0 +/- 3.4 microM.

Torilolone Dilution Calculator

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Torilolone Molarity Calculator

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Preparing Stock Solutions of Torilolone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.962 mL 19.8098 mL 39.6197 mL 79.2393 mL 99.0491 mL
5 mM 0.7924 mL 3.962 mL 7.9239 mL 15.8479 mL 19.8098 mL
10 mM 0.3962 mL 1.981 mL 3.962 mL 7.9239 mL 9.9049 mL
50 mM 0.0792 mL 0.3962 mL 0.7924 mL 1.5848 mL 1.981 mL
100 mM 0.0396 mL 0.1981 mL 0.3962 mL 0.7924 mL 0.9905 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Torilolone

Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells.[Pubmed:12221602]

Planta Med. 2002 Aug;68(8):748-9.

Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiterpenes, torilin (1) and Torilolone (2), together with a new derivative, 1-hydroxytorilin (3). Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 and 2 were 20.6 +/- 1.86 (P < 0.01) and 3.6 +/- 0.1 (P < 0.01) microM, respectively. Silybin as a positive control showed an EC50 value of 69.0 +/- 3.4 microM.

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