Metastasis

Metastasis is the spread of cancer from the primary neoplasm (tumor) to distant organs. As primary tumors can often be removed by surgery and radiation it is metastases that contribute to the majority of morbidity and mortality associated with cancer.

Metastasis Products Targets

Products for Metastasis - Page 3

Cat.No. Product Name Information/Activity
BCC7945 Phalloidin Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome (λex=495 nm, λem=520 nm).
BCC6162 SMIFH2 340316-62-3
BCC2391 ARRY 520 trifluoroacetate Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation,ARRY-520 is a synthetic kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
BCC2509 Ispinesib (SB-715992) Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
BCC7760 K858 K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.
BCC7978 Paprotrain Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
BCC4559 SB743921 SB-743921 is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.
BCC2911 H-Cys(Trt)-OH 2799-07-7
BCC1085 ABT-751 (E7010) ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.
BCC7274 CMPD-1 CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM.