Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 22

  1. Cat.No. Product Name Information/Activity
  2. BCC7312 SEW 2871 SEW2871 is a highly selective, orally active S1P1 agonist with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood and has therapeutic implications in contexts of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses. SEW 2871 chemical structure
  3. BCC7034 Sphingosine-1-phosphate Endogenous agonist at S1P<sub>1-5</sub> Sphingosine-1-phosphate chemical structure
  4. BCC6277 TC-G 1006 S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3. TC-G 1006 chemical structure
  5. BCC7926 TC-SP 14 Potent S1P<sub>1</sub> receptor agonist TC-SP 14 chemical structure
  6. BCC7348 JTE 013 547756-93-4 JTE 013 chemical structure
  7. BCC7883 VPC 23019 VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). VPC 23019 chemical structure
  8. BCC7723 W146 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. W146 chemical structure
  9. BCC7381 (±)-AC 7954 hydrochloride 477313-09-0 (±)-AC 7954 hydrochloride chemical structure
  10. BCC5796 Urotensin II (human) Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Urotensin II (human) chemical structure
  11. BCC8010 GSK 1562590 hydrochloride 1003878-07-6 GSK 1562590 hydrochloride chemical structure

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