Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 18

  1. Cat.No. Product Name Information/Activity
  2. BCC1332 AH 6809 AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors. AH 6809 chemical structure
  3. BCC7961 GW 627368 GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively. GW 627368 chemical structure
  4. BCC7393 L-161,982 L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice. L-161,982 chemical structure
  5. BCC7156 L-655,240 103253-15-2 L-655,240 chemical structure
  6. BCC5857 L-670,596 121083-05-4 L-670,596 chemical structure
  7. BCC7654 L-798,106 L-798106 is potent and highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM), it also has micromolar activities at the EP4, EP1 and EP2 receptors with Ki values of 916 nM, >5000 nM and >5000 nM at EP4, EP1 and EP2, respectively. L-798,106 chemical structure
  8. BCC1822 ONO-AE3-208 High affinity and selective EP<sub>4</sub> antagonist,ONO-AE3-208 is an <b>EP4</b> antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer. ONO-AE3-208 chemical structure
  9. BCC6299 PF 04418948 PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM. PF 04418948 chemical structure
  10. BCC6968 SC 19220 19395-87-0 SC 19220 chemical structure
  11. BCC7773 SC 51089 146033-02-5 SC 51089 chemical structure

Items 171 to 180 of 607 total