Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 15

  1. Cat.No. Product Name Information/Activity
  2. BCC6645 MY-5445 MY-5445 is a specific phosphodiesterase type 5 (PDE5) inhibitor. MY-5445 selectively inhibits cGMP PDE with a Ki of 1.3 μM. MY-5445 chemical structure
  3. BCC6215 Piclamilast 144035-83-6 Piclamilast chemical structure
  4. BCC6638 Ro 20-1724 29925-17-5 Ro 20-1724 chemical structure
  5. BCC2282 Rolipram Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. Rolipram chemical structure
  6. BCC5429 (R)-(-)-Rolipram (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. (R)-(-)-Rolipram chemical structure
  7. BCC2303 S- (+)-Rolipram (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer. S- (+)-Rolipram chemical structure
  8. BCC7645 RS 25344 hydrochloride 152815-28-6 RS 25344 hydrochloride chemical structure
  9. BCC6954 Siguazodan Siguazodan (SKF 94836) is a potent, selective and orally active phosphodiesterase III (PDE-III) inhibitor with an IC50 of 117 nM. Siguazodan increases cAMP accumulation in intact platelets with an EC50 of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC50 value of 4.2 μM. Siguazodan chemical structure
  10. BCC2276 Sildenafil Citrate Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM. Sildenafil Citrate chemical structure
  11. BCC5803 T 0156 hydrochloride 324572-93-2 T 0156 hydrochloride chemical structure

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