Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 12

  1. Cat.No. Product Name Information/Activity
  2. BCC6004 AR-C 66096 tetrasodium salt Potent and selective P2Y<sub>12</sub> antagonist AR-C 66096 tetrasodium salt chemical structure
  3. BCC2497 Clopidogrel Clopidogrel hydrogen sulfate is an antiplatelet agent which works by blocking platelets from sticking together and prevents them from forming harmful clots. Clopidogrel chemical structure
  4. BCC5685 MRS 2179 tetrasodium salt 1454889-37-2 MRS 2179 tetrasodium salt chemical structure
  5. BCC5880 MRS 2279 367909-40-8 MRS 2279 chemical structure
  6. BCC5881 MRS 2500 tetraammonium salt 630103-23-0 MRS 2500 tetraammonium salt chemical structure
  7. BCC4976 MRS 2578 MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors. MRS 2578 chemical structure
  8. BCC7367 NF 157 NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 µM, 170 µM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 µM), P2Y2 (Ki=28.9 µM), respectively. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA). NF 157 chemical structure
  9. BCC7785 NF 340 202982-98-7 NF 340 chemical structure
  10. BCC6725 PPADS tetrasodium salt PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺exchanger in guinea pig airway smooth muscle. PPADS tetrasodium salt chemical structure
  11. BCC6095 PSB 0739 1052087-90-7 PSB 0739 chemical structure

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