Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 5

  1. Cat.No. Product Name Information/Activity
  2. BCC4428 Etodolac Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM) Etodolac chemical structure
  3. BCC1576 FK 3311 FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of COX-2 with antiinflammatory agent. FK 3311 chemical structure
  4. BCC3781 Flurbiprofen Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Flurbiprofen chemical structure
  5. BCC7092 FR 122047 hydrochloride 130717-51-0 FR 122047 hydrochloride chemical structure
  6. BCC4042 (S)-(+)-Ibuprofen (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects. (S)-(+)-Ibuprofen chemical structure
  7. BCC3794 Indomethacin Indomethacin (Indometacin) is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin chemical structure
  8. BCC6490 Naproxen Sodium Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Naproxen Sodium chemical structure
  9. BCC7944 NCX 4040 287118-97-2 NCX 4040 chemical structure
  10. BCC6219 NCX 466 1262956-64-8 NCX 466 chemical structure
  11. BCC6857 NS 398 NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM. NS 398 chemical structure

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